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Tbio
IKZF1
DNA-binding protein Ikaros

Protein Summary
Description
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067). Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067). This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331340
  • ENSP00000331614
  • ENSG00000185811
  • ENST00000343574
  • ENSP00000342750
  • ENST00000349824
  • ENSP00000342485
  • ENST00000357364
  • ENSP00000349928
  • ENST00000359197
  • ENSP00000352123
  • ENST00000438033
  • ENSP00000396554
  • ENST00000439701
  • ENSP00000413025
  • ENST00000644005
  • ENSP00000496453

Symbol
  • IK1
  • IKAROS
  • LYF1
  • ZNFN1A1
  • IK1
  • LYF1
  • LyF-1
  • CVID13
  • IKAROS
  • PPP1R92
  • PRO0758
  • ZNFN1A1
  • Hs.54452
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
PubMedID
0.77
hub protein
0.71
kinase perturbation
0.71
small molecule perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.85   (req: < 5)
Gene RIFs: 289   (req: <= 3)
Antibodies: 511   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.85   (req: >= 5)
Gene RIFs: 289   (req: > 3)
Antibodies: 511   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0