Tchem ILK Integrin-linked protein kinase

Protein Summary

Description

Receptor-proximal protein kinase regulating integrin-mediated signal transduction (PubMed:8538749, PubMed:9736715). May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B (PubMed:8538749, PubMed:9736715). This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q13418
• B7Z1I0
• B7Z418
• D3DQU0
• P57043
• Q68DZ3

Gene Name

• ILK

Ensembl ID

• ENST00000299421
• ENSP00000299421
• ENSG00000166333
• ENST00000396751
• ENSP00000379975
• ENST00000420936
• ENSP00000403487
• ENST00000528995
• ENSP00000435323
• ENST00000532063
• ENSP00000434492

Symbol

• ILK1
• ILK2
• P59
• ILK-1
• ILK-2
• p59ILK
• HEL-S-28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
disease perturbation	0.99
interacting protein	0.99
molecular function	0.99
kinase perturbation	0.88

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Ilk Subfamily / Integrin-linked Protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.65   (req: < 5)

Gene RIFs: 243   (req: <= 3)

Antibodies: 727   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.65   (req: >= 5)

Gene RIFs: 243   (req: > 3)

Antibodies: 727   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1