You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ORC2
Origin recognition complex subunit 2

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, w ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234296
  • ENSP00000234296
  • ENSG00000115942

Symbol
  • ORC2L
  • ORC2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
interacting protein
0.88
ligand (protein) perturbation
0.83
hub protein
0.79
transcription factor binding site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
17.8
mean corpuscular volume
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
17.8
mean corpuscular volume
1
9.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 2
VGNC:2737
459868
Macaque
origin recognition complex subunit 2
700691
Mouse
MGI:1328306
18393
Rat
RGD:1311844
301430
Dog
origin recognition complex subunit 2
VGNC:44141
478868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 2
Macaque
origin recognition complex subunit 2
Mouse
Rat
Dog
origin recognition complex subunit 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13416-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (167)
1 – 10 of 167
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
ORC6
Tbio
Novelty:  0.02529139
p_int:  0.999999971
p_ni:  1.5e-8
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RPGR
Tbio
Family:  Enzyme
Novelty:  0.002733
p_int:  0.999998973
p_ni:  9.15e-7
p_wrong:  1.12e-7
Score:  0.296
Data Source:  BioPlex,STRINGDB
STN1
Tbio
Novelty:  0.01309587
p_int:  0.999995832
p_ni:  0.000004101
p_wrong:  6.7e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.999961248
p_ni:  0.000032321
p_wrong:  0.000006432
Score:  0.309
Data Source:  BioPlex,STRINGDB
SLIRP
Tbio
Novelty:  0.04630917
p_int:  0.998368503
p_ni:  0.000120524
p_wrong:  0.001510973
Data Source:  BioPlex
MCM10
Tbio
Novelty:  0.0136058
Score:  0.999
Data Source:  STRINGDB
MCM7
Tbio
Novelty:  0.0017984
Score:  0.999
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.999
Data Source:  STRINGDB
ORC4
Tbio
Novelty:  0.01763127
Score:  0.999
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  7.61

PubMed score by year
PubTator Score  47.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer