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Tbio
ORC1
Origin recognition complex subunit 1

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylate ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371566
  • ENSP00000360621
  • ENSG00000085840
  • ENST00000371568
  • ENSP00000360623

Symbol
  • ORC1L
  • PARC1
  • ORC1L
  • PARC1
  • HSORC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
histone modification site profile
0.93
molecular function
0.86
gene perturbation
0.85
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.84   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
17.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 1
VGNC:6141
456857
Mouse
MGI:1328337
18392
Rat
RGD:631435
313479
Dog
origin recognition complex subunit 1
VGNC:44140
100855917
Horse
origin recognition complex subunit 1
VGNC:21050
100061980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 1
Mouse
Rat
Dog
origin recognition complex subunit 1
Horse
origin recognition complex subunit 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13415-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (313)
1 – 10 of 313
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999999766
p_ni:  2.24e-7
p_wrong:  1e-8
Data Source:  BioPlex
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999996517
p_ni:  0.000001898
p_wrong:  0.000001585
Score:  0.993
Data Source:  BioPlex,STRINGDB
ORC3
Tbio
Novelty:  0.03409802
Score:  0.999
Data Source:  Reactome,STRINGDB
MCM3
Tbio
Novelty:  0.00593382
Score:  0.999
Data Source:  STRINGDB
MCM6
Tbio
Novelty:  0.00675724
Score:  0.999
Data Source:  STRINGDB
MCM2
Tbio
Novelty:  0.00276275
Score:  0.999
Data Source:  STRINGDB
MCM5
Tbio
Novelty:  0.00716583
Score:  0.999
Data Source:  STRINGDB
CDC45
Tbio
Novelty:  0.00515457
Score:  0.999
Data Source:  STRINGDB
CDC6
Tbio
Novelty:  0.00219371
Score:  0.999
Data Source:  STRINGDB
ORC2
Tbio
Novelty:  0.11963517
Score:  0.999
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  36.84

PubMed score by year
PubTator Score  61.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer