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Tbio
DYNC1I2
Cytoplasmic dynein 1 intermediate chain 2

Protein Summary
Description
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340296
  • ENSP00000339430
  • ENSG00000077380
  • ENST00000397119
  • ENSP00000380308
  • ENST00000409197
  • ENSP00000386397
  • ENST00000409317
  • ENSP00000386591
  • ENST00000409453
  • ENSP00000386886
  • ENST00000409773
  • ENSP00000386415
  • ENST00000410079
  • ENSP00000386522
  • ENST00000508530
  • ENSP00000423339

Symbol
  • DNCI2
  • DNCIC2
  • IC2
  • DIC74
  • DNCI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
co-expressed gene
0.98
virus perturbation
0.94
transcription factor binding site profile
0.85
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.19   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.19   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0