Tbio DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2

Protein Summary

Description

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q13409
• B7ZA04
• D3DPD4
• D3DPD5
• D3DPD6
• Q32LY9
• Q53S84
• Q5BJF8
• Q7Z4X1
• Q96NG7
• Q96S87
• Q9BXZ5
• Q9NT58

Gene Name

• DYNC1I2

Ensembl ID

• ENST00000340296
• ENSP00000339430
• ENSG00000077380
• ENST00000397119
• ENSP00000380308
• ENST00000409197
• ENSP00000386397
• ENST00000409317
• ENSP00000386591
• ENST00000409453
• ENSP00000386886
• ENST00000409773
• ENSP00000386415
• ENST00000410079
• ENSP00000386522
• ENST00000508530
• ENSP00000423339

Symbol

• DNCI2
• DNCIC2
• IC2
• DIC74
• DNCI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
co-expressed gene	0.98
virus perturbation	0.94
transcription factor binding site profile	0.85
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 1 Intermediate Chain 2

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Cytoplasmic Dynein 1 Intermediate Chain 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.19   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 128   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 648.19   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0