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Tbio
MRPL49
39S ribosomal protein L49, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes corresponding to this gene are found on chromosomes 5q and 8p. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279242
  • ENSP00000279242
  • ENSG00000149792
  • ENST00000526319
  • ENSP00000434190

Symbol
  • C11orf4
  • NOF1
  • NOF
  • NOF1
  • L49mt
  • C11orf4
  • MRP-L49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
virus perturbation
0.9
transcription factor binding site profile
0.82
histone modification site profile
0.8
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L49
VGNC:3105
466659
Macaque
mitochondrial ribosomal protein L49
716796
Mouse
MGI:108180
18120
Rat
RGD:1309920
309176
Dog
mitochondrial ribosomal protein L49
VGNC:43402
483747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L49
Macaque
mitochondrial ribosomal protein L49
Mouse
Rat
Dog
mitochondrial ribosomal protein L49
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13405-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (153)
1 – 10 of 153
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.99987825
p_ni: 0.00012175
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999804554
p_ni: 0.000195446
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.998973068
p_ni: 0.001026932
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.99891824
p_ni: 0.00108176
Score: 0.985
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.99775414
p_ni: 0.00224586
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL13
Tbio
Novelty: 0.04173503
p_int: 0.997458211
p_ni: 0.002541789
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.996898602
p_ni: 0.003101398
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.991686627
p_ni: 0.008313373
Score: 0.984
Data Source: BioPlex,STRINGDB
RPL37
Tbio
Novelty: 0.03935854
p_int: 0.988803842
p_ni: 0.011196158
Data Source: BioPlex
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.988708524
p_ni: 0.011291476
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  63.74

PubMed score by year
PubTator Score  39.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer