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Tbio
UBE2V1
Ubiquitin-conjugating enzyme E2 variant 1

Protein Summary
Description
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340309
  • ENSP00000340305
  • ENSG00000244687
  • ENST00000371657
  • ENSP00000360720
  • ENST00000371674
  • ENSP00000360739
  • ENST00000371677
  • ENSP00000360742
  • ENST00000415862
  • ENSP00000407770

Symbol
  • CROC1
  • UBE2V
  • UEV1
  • CROC1B
  • CROC-1B
  • KUA-UEV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
cellular component
0.78
transcription factor binding site profile
0.78
pathway
0.73
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (376)
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.998
Data Source:  Reactome,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
Score:  0.996
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.991
Data Source:  STRINGDB
UBE2B
Tchem
Novelty:  0.01578275
Score:  0.991
Data Source:  STRINGDB
UBE2C
Tbio
Novelty:  0.00731185
Score:  0.991
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.989
Data Source:  STRINGDB
UBE2V2
Tbio
Novelty:  0.01112479
Score:  0.982
Data Source:  STRINGDB
UBE2D3
Tchem
Novelty:  0.01908446
Score:  0.98
Data Source:  STRINGDB
UBE2D1
Tbio
Novelty:  0.00865867
Score:  0.98
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (55)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
73.2
3
2
1
1
69.3
granulocyte percentage of myeloid white cells
1
1
1
66.3
body fat percentage
1
1
1
9.4
BMI-adjusted hip circumference
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
73.2
1
1
69.3
granulocyte percentage of myeloid white cells
1
66.3
body fat percentage
1
9.4
BMI-adjusted hip circumference
1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 V1
100538342
Mouse
MGI:1913839
66589
Rat
RGD:1305503
296390
Dog
ubiquitin conjugating enzyme E2 V1
VGNC:54739
100538347
Horse
ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol;Acc:HGNC:12494]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin conjugating enzyme E2 V1
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 V1
Horse
ubiquitin conjugating enzyme E2 V1 [Source:HGNC Symbol;Acc:HGNC:12494]
Publication Statistics
PubMed Score 54.23
PubMed score by year
PubTator Score 0.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title