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Tbio
UBE2V1
Ubiquitin-conjugating enzyme E2 variant 1

Protein Summary
Description
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through tr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340309
  • ENSP00000340305
  • ENSG00000244687
  • ENST00000371657
  • ENSP00000360720
  • ENST00000371674
  • ENSP00000360739
  • ENST00000371677
  • ENSP00000360742
  • ENST00000415862
  • ENSP00000407770

Symbol
  • CROC1
  • UBE2V
  • UEV1
  • CROC1B
  • CROC-1B
  • KUA-UEV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
cellular component
0.78
transcription factor binding site profile
0.78
pathway
0.73
tissue sample
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (55)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 43
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (376)
1 – 10 of 376
UBE2N
Tbio
Novelty: 0.00723255
Score: 0.998
Data Source: Reactome,STRINGDB
UBE2D2
Tbio
Novelty: 0.00827182
Score: 0.996
Data Source: STRINGDB
STUB1
Tbio
Family: Enzyme
Novelty: 0.00091876
Score: 0.991
Data Source: STRINGDB
UBE2B
Tbio
Novelty: 0.02464704
Score: 0.991
Data Source: STRINGDB
UBE2C
Tbio
Novelty: 0.01031039
Score: 0.991
Data Source: STRINGDB
UBE2K
Tbio
Novelty: 0.00169562
Score: 0.989
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01761532
Score: 0.982
Data Source: STRINGDB
UBE2D3
Tbio
Novelty: 0.03222096
Score: 0.98
Data Source: STRINGDB
UBE2D1
Tbio
Novelty: 0.00202514
Score: 0.98
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.85

PubMed score by year
PubTator Score  0.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer