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Tbio
MYO7A
Unconventional myosin-VIIa

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. This gene is a member of the myosin gene family. Myosins are mechano ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409619
  • ENSP00000386635
  • ENSG00000137474
  • ENST00000409709
  • ENSP00000386331
  • ENST00000458637
  • ENSP00000392185

Symbol
  • USH1B
  • DFNB2
  • MYU7A
  • NSRD2
  • USH1B
  • DFNA11
  • MYOVIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
cellular component
0.77
phenotype
0.72
cell line
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.78   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.78   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VIIA
VGNC:12644
466717
Macaque
myosin VIIA
699411
Mouse
MGI:104510
17921
Rat
RGD:628830
266714
Dog
myosin VIIA
VGNC:43572
485174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VIIA
Macaque
myosin VIIA
Mouse
Rat
Dog
myosin VIIA
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13402-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
The canonical retinoid cycle in rods (twilight vision)
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
The canonical retinoid cycle in rods (twilight vision)
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (139)
1 – 10 of 139
LANCL1
Tbio
Novelty: 0.06479031
p_int: 0.960189819
p_ni: 0.000034848
p_wrong: 0.039775332
Score: 0.56
Data Source: BioPlex,STRINGDB
USH1C
Tbio
Novelty: 0.01066917
Score: 0.972
Data Source: STRINGDB
CDH23
Tbio
Novelty: 0.00588227
Score: 0.968
Data Source: STRINGDB
PCDH15
Tbio
Novelty: 0.0097699
Score: 0.937
Data Source: STRINGDB
WHRN
Tbio
Novelty: 0.01886351
Score: 0.899
Data Source: STRINGDB
USH1G
Tbio
Novelty: 0.02912203
Score: 0.894
Data Source: STRINGDB
MYRIP
Tbio
Novelty: 0.06456504
Score: 0.875
Data Source: STRINGDB
PDZD7
Tbio
Novelty: 0.09467006
Score: 0.857
Data Source: STRINGDB
USH2A
Tbio
Novelty: 0.00223387
Score: 0.855
Data Source: STRINGDB
VEZT
Tbio
Novelty: 0.06274137
Score: 0.852
Data Source: STRINGDB
Publication Statistics
PubMed Score  319.78

PubMed score by year
PubTator Score  176.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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