Protein Summary
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
- ENST00000351298
- ENSP00000342793
- ENSG00000075651
- ENST00000356327
- ENSP00000348681
- CVDD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.96 | ||
protein domain | 0.92 | ||
PubMedID | 0.88 | ||
transcription factor binding site profile | 0.84 | ||
histone modification site profile | 0.83 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.11 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 196.11 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 90
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (90)
1 – 10 of 90
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 6 | 15 | 94.3 | |||||
eosinophil count | 2 | 2 | 2 | 69.7 | |||||
reticulocyte measurement | 1 | 1 | 1 | 7.3 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 15 | 94.3 | |||||
eosinophil count | 2 | 69.7 | |||||
reticulocyte measurement | 1 | 7.3 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase D1 | VGNC:7084 | 470996 | |||||
Macaque | phospholipase D1 | 694963 | ||||||
Mouse | MGI:109585 | 18805 | ||||||
Rat | RGD:3349 | 25096 | ||||||
Dog | phospholipase D1 | VGNC:44660 | 488167 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase D1 | |||||
Macaque | phospholipase D1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase D1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (74)
Reactome (11)
KEGG (15)
PathwayCommons (13)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Glycerophospholipid biosynthesis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Gene Ontology Terms (27)
Functions (3)
Components (14)
Processes (10)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (359)
1 – 10 of 359
HEATR3
Novelty: 0.08367436
p_int: 0.999986933
p_ni: 0.000013067
Data Source: BioPlex
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.999966979
p_ni: 0.000033021
Score: 0.153
Data Source: BioPlex,STRINGDB
EIF2B5
Novelty: 0.0102209
p_int: 0.999958735
p_ni: 0.000041264
Data Source: BioPlex
CACNG5
Family: IC
Novelty: 0.52705448
p_int: 0.999954605
p_ni: 0.000045395
Data Source: BioPlex
TMEM63C
Family: IC
Novelty: 0.02849254
p_int: 0.999915076
p_ni: 0.000084924
Data Source: BioPlex
UBE2O
Novelty: 0.07084123
p_int: 0.999771167
p_ni: 0.000228833
Data Source: BioPlex
CDH5
Novelty: 0.00072649
p_int: 0.999629784
p_ni: 0.000370216
Data Source: BioPlex
TEX264
Novelty: 0.32406417
p_int: 0.997242649
p_ni: 0.002757351
Data Source: BioPlex
AHCYL1
Family: Enzyme
Novelty: 0.02176432
p_int: 0.996762923
p_ni: 0.003237031
p_wrong: 4.7e-8
Data Source: BioPlex
ZRANB2
Novelty: 0.06105086
p_int: 0.994896637
p_ni: 0.005103363
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score 196.11
PubMed score by year
PubTator Score 243.21
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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