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Tchem
PLD1
Phospholipase D1

Protein Summary
Description
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351298
  • ENSP00000342793
  • ENSG00000075651
  • ENST00000356327
  • ENSP00000348681

Symbol
  • CVDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.96
protein domain
0.92
PubMedID
0.88
transcription factor binding site profile
0.84
histone modification site profile
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.11   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.11   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 90
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
6
15
94.3
eosinophil count
2
2
2
69.7
reticulocyte measurement
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
15
94.3
eosinophil count
2
69.7
reticulocyte measurement
1
7.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase D1
VGNC:7084
470996
Macaque
phospholipase D1
694963
Mouse
MGI:109585
18805
Rat
RGD:3349
25096
Dog
phospholipase D1
VGNC:44660
488167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase D1
Macaque
phospholipase D1
Mouse
Rat
Dog
phospholipase D1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13393-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (74)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Glycerophospholipid biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Glycerophospholipid biosynthesis
Immune System
Innate Immune System
Metabolism
Protein-Protein Interactions (359)
1 – 10 of 359
HEATR3
Tbio
Novelty: 0.08367436
p_int: 0.999986933
p_ni: 0.000013067
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.999966979
p_ni: 0.000033021
Score: 0.153
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.999958735
p_ni: 0.000041264
Data Source: BioPlex
CACNG5
Tdark
Family: IC
Novelty: 0.52705448
p_int: 0.999954605
p_ni: 0.000045395
Data Source: BioPlex
TMEM63C
Tdark
Family: IC
Novelty: 0.02849254
p_int: 0.999915076
p_ni: 0.000084924
Data Source: BioPlex
UBE2O
Tbio
Novelty: 0.07084123
p_int: 0.999771167
p_ni: 0.000228833
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.999629784
p_ni: 0.000370216
Data Source: BioPlex
TEX264
Tdark
Novelty: 0.32406417
p_int: 0.997242649
p_ni: 0.002757351
Data Source: BioPlex
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.996762923
p_ni: 0.003237031
p_wrong: 4.7e-8
Data Source: BioPlex
ZRANB2
Tbio
Novelty: 0.06105086
p_int: 0.994896637
p_ni: 0.005103363
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  196.11

PubMed score by year
PubTator Score  243.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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