Protein Summary
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
- ENST00000351298
- ENSP00000342793
- ENSG00000075651
- ENST00000356327
- ENSP00000348681
- CVDD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 0.96 | ||
protein domain | 0.92 | ||
PubMedID | 0.88 | ||
transcription factor binding site profile | 0.84 | ||
histone modification site profile | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.13 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.13 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 100
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (100)
Protein-Protein Interactions (359)
GPR156
Family: GPCR
Novelty: 0.39183023
p_int: 0.999966979
p_ni: 0.000033021
Score: 0.153
Data Source: BioPlex,STRINGDB
TMEM63C
Family: IC
Novelty: 0.02849254
p_int: 0.999915076
p_ni: 0.000084924
Data Source: BioPlex
AHCYL1
Family: Enzyme
Novelty: 0.02176432
p_int: 0.996762923
p_ni: 0.003237031
p_wrong: 4.7e-8
Data Source: BioPlex
ZRANB2
Novelty: 0.06105086
p_int: 0.994896637
p_ni: 0.005103363
p_wrong: 1e-9
Data Source: BioPlex
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (74)
Reactome (11)
KEGG (15)
PathwayCommons (13)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Reactome | Glycerophospholipid biosynthesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Glycerophospholipid biosynthesis | ||||
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (3)
Components (14)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 6 | 15 | 99 | |||||
eosinophil count | 2 | 2 | 2 | 69.6 | |||||
intraocular pressure measurement | 1 | 1 | 1 | 61 | |||||
HbA1c measurement | 1 | 1 | 1 | 30.2 | |||||
reticulocyte measurement | 1 | 1 | 1 | 27.3 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 15 | 99 | |||||
eosinophil count | 2 | 69.6 | |||||
intraocular pressure measurement | 1 | 61 | |||||
HbA1c measurement | 1 | 30.2 | |||||
reticulocyte measurement | 1 | 27.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phospholipase D1 | VGNC:7084 | 470996 | |||||
Macaque | phospholipase D1 | 694963 | ||||||
Mouse | MGI:109585 | 18805 | ||||||
Rat | RGD:3349 | 25096 | ||||||
Dog | phospholipase D1 | VGNC:44660 | 488167 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phospholipase D1 | |||||
Macaque | phospholipase D1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phospholipase D1 | |||||
Publication Statistics
PubMed Score 197.13
PubMed score by year
PubTator Score 243.21
PubTator score by year
Related Publications
Text Mined References (145)
GeneRif Annotations (108)
Items per page:
0 of 0
PMID | Year | Title |
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