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Tbio
MAPK8IP2
C-Jun-amino-terminal kinase-interacting protein 2

Protein Summary
Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329492
  • ENSP00000330572
  • ENSG00000008735

Symbol
  • IB2
  • JIP2
  • PRKM8IPL
  • IB2
  • IB-2
  • JIP2
  • PRKM8IPL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
tissue sample
0.69
molecular function
0.63
PubMedID
0.61
hub protein
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
MAPK8IP3
Tbio
Family:  Enzyme
Novelty:  0.01127812
p_int:  0.999999556
p_ni:  2.1e-7
p_wrong:  2.33e-7
Score:  0.945
Data Source:  BioPlex,STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
p_int:  0.999999244
p_ni:  6.87e-7
p_wrong:  6.9e-8
Score:  0.972
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.999999151
p_ni:  8.49e-7
Score:  0.657
Data Source:  BioPlex,STRINGDB
RAPGEF5
Tbio
Novelty:  0.02449802
p_int:  0.99999654
p_ni:  0.000003289
p_wrong:  1.71e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
BTF3
Tbio
Novelty:  0.01198537
p_int:  0.999289569
p_ni:  0.000541197
p_wrong:  0.000169234
Data Source:  BioPlex
TULP2
Tdark
Family:  TF
Novelty:  0.20144336
p_int:  0.992631546
p_ni:  0.00004728
p_wrong:  0.007321173
Score:  0.16
Data Source:  BioPlex,STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.953
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.938
Data Source:  STRINGDB
MAP3K11
Tchem
Family:  Kinase
Novelty:  0.01112378
Score:  0.935
Data Source:  STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.929
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
99
mean reticulocyte volume
1
4
4
97.6
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
99
mean reticulocyte volume
4
97.6
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 2
VGNC:7342
458945
Mouse
MGI:1926555
60597
Rat
RGD:1309727
315220
Dog
mitogen-activated protein kinase 8 interacting protein 2
VGNC:43002
481183
Cow
mitogen-activated protein kinase 8 interacting protein 2
VGNC:31225
618893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 8 interacting protein 2
Mouse
Rat
Dog
mitogen-activated protein kinase 8 interacting protein 2
Cow
mitogen-activated protein kinase 8 interacting protein 2
Publication Statistics
PubMed Score 58.51
PubMed score by year
PubTator Score 485.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title