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Tclin
PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase B

Protein Summary
Description
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282096
  • ENSP00000282096
  • ENSG00000152270
  • ENST00000455098
  • ENSP00000388644

Symbol
  • HcGIP1
  • cGIPDE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
microRNA
0.82
kinase perturbation
0.76
disease perturbation
0.74
PubMedID
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 82
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (169)
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999087928
p_ni:  0.000912072
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.997668134
p_ni:  0.002331866
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.984572714
p_ni:  0.015427285
p_wrong:  1e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
PCDHAC2
Tbio
Novelty:  0.28397695
p_int:  0.950408126
p_ni:  0.049591874
Data Source:  BioPlex
P01911
Tchem
Novelty:  0.00240724
p_int:  0.926139805
p_ni:  0.073860195
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.925918755
p_ni:  0.074081245
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.923638178
p_ni:  0.07636182
p_wrong:  1e-9
Data Source:  BioPlex
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
p_int:  0.902823212
p_ni:  0.097176788
Data Source:  BioPlex
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.900196295
p_ni:  0.099803705
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.889196748
p_ni:  0.110803252
Score:  0.198
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (150)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
IGF1R signaling cascade
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
G alpha (s) signalling events
GPCR downstream signalling
IGF1R signaling cascade
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
15
31
39
6.3
100
seasonality measurement
1
1
0
21.1
94.9
high density lipoprotein cholesterol measurement
5
2
5
93.4
vitamin D deficiency
1
1
1
93
BMI-adjusted waist-hip ratio
5
4
7
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
39
6.3
100
seasonality measurement
0
21.1
94.9
high density lipoprotein cholesterol measurement
5
93.4
vitamin D deficiency
1
93
BMI-adjusted waist-hip ratio
7
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphodiesterase 3B
698954
Mouse
MGI:1333863
18576
Rat
RGD:61943
29516
Cow
phosphodiesterase 3B
VGNC:32675
533323
Opossum
phosphodiesterase 3B
100029160
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphodiesterase 3B
Mouse
Rat
Cow
phosphodiesterase 3B
Opossum
phosphodiesterase 3B
Publication Statistics
PubMed Score 117.23
PubMed score by year
PubTator Score 258.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title