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Tbio
CTBP1
C-terminal-binding protein 1

Protein Summary
Description
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290921
  • ENSP00000290921
  • ENSG00000159692
  • ENST00000382952
  • ENSP00000372411

Symbol
  • CTBP
  • BARS
  • HADDTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.95
hub protein
0.95
molecular function
0.95
biological process
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.02   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 610   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.02   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 610   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
97.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
97.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-terminal binding protein 1
VGNC:2956
738792
Macaque
C-terminal binding protein 1
694507
Mouse
MGI:1201685
13016
Rat
RGD:2441
29382
Dog
C-terminal binding protein 1
VGNC:39686
612240
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-terminal binding protein 1
Macaque
C-terminal binding protein 1
Mouse
Rat
Dog
C-terminal binding protein 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13363-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (105)
Deactivation of the beta-catenin transactivating complex (R-HSA-3769402)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Disease
Diseases of signal transduction
Metabolism of proteins
Gene Ontology Terms (27)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (217)
1 – 10 of 217
ZEB1
Tbio
Family: TF
Novelty: 0.00085257
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
PRDM2
Tbio
Family: TF; Epigenetic
Novelty: 0.00556321
p_int: 1
Score: 0.393
Data Source: BioPlex,STRINGDB
LCOR
Tbio
Family: TF
Novelty: 0.01638762
p_int: 0.999999998
p_ni: 2e-9
Score: 0.745
Data Source: BioPlex,STRINGDB
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999983
p_ni: 1.7e-8
Score: 0.948
Data Source: BioPlex,STRINGDB
LCORL
Tbio
Family: TF
Novelty: 0.02730877
p_int: 0.999999981
p_wrong: 1.9e-8
Score: 0.429
Data Source: BioPlex,STRINGDB
ZNF217
Tbio
Family: TF
Novelty: 0.01313576
p_int: 0.999999978
p_ni: 2.2e-8
Score: 0.881
Data Source: BioPlex,STRINGDB
NOL4
Tbio
Novelty: 0.04108058
p_int: 0.999999899
p_ni: 8.8e-8
p_wrong: 1.2e-8
Score: 0.32
Data Source: BioPlex,STRINGDB
TRPS1
Tbio
Family: TF
Novelty: 0.0075626
p_int: 0.999999147
p_ni: 8.53e-7
Score: 0.359
Data Source: BioPlex,STRINGDB
ZEB2
Tbio
Family: TF
Novelty: 0.00177023
p_int: 0.99999908
p_ni: 3.3e-8
p_wrong: 8.87e-7
Score: 0.712
Data Source: BioPlex,STRINGDB
HIC2
Tbio
Family: TF
Novelty: 0.1544738
p_int: 0.999998884
p_ni: 0.000001116
Score: 0.353
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  313.02

PubMed score by year
PubTator Score  93.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer