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Tbio
PPP2R5C
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328724
  • ENSP00000329009
  • ENSG00000078304
  • ENST00000334743
  • ENSP00000333905
  • ENST00000350249
  • ENSP00000262239
  • ENST00000422945
  • ENSP00000412324
  • ENST00000445439
  • ENSP00000408389

Symbol
  • KIAA0044
  • B56G
  • PR61G
  • B56gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
virus perturbation
0.99
transcription factor
0.85
histone modification site profile
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.23   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.23   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'gamma
VGNC:12583
453170
Macaque
protein phosphatase 2 regulatory subunit B'gamma
718894
Mouse
MGI:1349475
26931
Rat
RGD:1585097
691318
Dog
protein phosphatase 2 regulatory subunit B'gamma
VGNC:44915
480436
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'gamma
Macaque
protein phosphatase 2 regulatory subunit B'gamma
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B'gamma
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13362-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (82)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 63
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Protein-Protein Interactions (306)
1 – 10 of 306
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999980337
p_ni: 0.000019663
Score: 0.999
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999961424
p_ni: 0.000038576
Score: 0.993
Data Source: BioPlex,STRINGDB
PRR14
Tbio
Novelty: 0.22401806
p_int: 0.999853737
p_ni: 0.000146263
Score: 0.747
Data Source: BioPlex,STRINGDB
FAM43A
Tdark
Novelty: 1.17401589
p_int: 0.991609527
p_ni: 0.008390473
Score: 0.211
Data Source: BioPlex,STRINGDB
CCNG2
Tbio
Novelty: 0.01824057
p_int: 0.913518741
p_ni: 0.086481259
Score: 0.607
Data Source: BioPlex,STRINGDB
CCNG1
Tbio
Novelty: 0.00838635
p_int: 0.913241692
p_ni: 0.086758308
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.999
Data Source: STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
Score: 0.998
Data Source: STRINGDB
PPP2R2A
Tchem
Family: Enzyme
Novelty: 0.01723628
Score: 0.995
Data Source: STRINGDB
SGO1
Tbio
Novelty: 0.01115849
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.23

PubMed score by year
PubTator Score  10.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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