PPP2R5C
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Protein Summary
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Al ...more
- ENST00000328724
- ENSP00000329009
- ENSG00000078304
- ENST00000334743
- ENSP00000333905
- ENST00000350249
- ENSP00000262239
- ENST00000422945
- ENSP00000412324
- ENST00000445439
- ENSP00000408389
- KIAA0044
- B56G
- PR61G
- B56gamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
kinase perturbation | 0.99 | ||
virus perturbation | 0.99 | ||
transcription factor | 0.85 | ||
histone modification site profile | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.55 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.55 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0