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Tbio
PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

Protein Summary
Description
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335025
  • ENSP00000334553
  • ENSG00000100023
  • ENST00000398831
  • ENSP00000381812
  • ENST00000406385
  • ENSP00000384299
  • ENST00000626352
  • ENSP00000486725

Symbol
  • CYC4
  • CYP60
  • UBOX7
  • Cyp-60
  • hCyP-60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.87
protein domain
0.85
kinase perturbation
0.84
small molecule perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999999646
p_ni:  3.54e-7
Data Source:  BioPlex
ZNF830
Tdark
Novelty:  0.38957008
p_int:  0.999997176
p_ni:  0.000002823
p_wrong:  1e-9
Score:  0.801
Data Source:  BioPlex,STRINGDB
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.990328079
p_ni:  0.009671921
Score:  0.188
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.988833889
p_ni:  0.011166111
Score:  0.179
Data Source:  BioPlex,STRINGDB
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.948019378
p_ni:  0.051980622
Data Source:  BioPlex
FKBP6
Tbio
Family:  Enzyme
Novelty:  0.02240256
p_int:  0.929304289
p_ni:  0.070695711
Score:  0.279
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.880718699
p_ni:  0.119281301
Score:  0.163
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.820019642
p_ni:  0.179980358
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
Score:  0.978
Data Source:  Reactome,STRINGDB
PRCC
Tbio
Novelty:  0.00836323
Score:  0.896
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
8
16
97.3
mean corpuscular hemoglobin concentration
4
4
4
97.2
mean corpuscular volume
4
4
4
93.6
apolipoprotein A 1 measurement
2
2
2
91.5
6
4
0
1.2
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
16
97.3
mean corpuscular hemoglobin concentration
4
97.2
mean corpuscular volume
4
93.6
apolipoprotein A 1 measurement
2
91.5
0
1.2
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl isomerase like 2
700024
Mouse
MGI:2447857
66053
Rat
RGD:1309484
360746
Dog
peptidylprolyl isomerase like 2
VGNC:44856
477573
Cow
peptidylprolyl isomerase like 2
VGNC:33202
511467
Species
Name
OMA
EggNOG
Inparanoid
Macaque
peptidylprolyl isomerase like 2
Mouse
Rat
Dog
peptidylprolyl isomerase like 2
Cow
peptidylprolyl isomerase like 2
Publication Statistics
PubMed Score 22.23
PubMed score by year
PubTator Score 11.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title