Tbio PPIL2 RING-type E3 ubiquitin-protein ligase PPIL2

Protein Summary

Description

Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q13356
• Q13357
• Q8TAH2
• Q9BWR8

Gene Name

• PPIL2

Ensembl ID

• ENST00000335025
• ENSP00000334553
• ENSG00000100023
• ENST00000398831
• ENSP00000381812
• ENST00000406385
• ENSP00000384299
• ENST00000626352
• ENSP00000486725

Symbol

• CYC4
• CYP60
• UBOX7
• Cyp-60
• hCyP-60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
disease perturbation	0.87
protein domain	0.85
kinase perturbation	0.84
small molecule perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Isomerase / Ring-type E3 Ubiquitin-protein Ligase Ppil2

DTO Classes

Protein / Enzyme / Isomerase / Peptidyl-prolyl Cis-trans Isomerase-like 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.95   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.95   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0