Tbio SP140 Nuclear body protein SP140

Protein Summary

Description

Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]

Uniprot Accession IDs

• Q13342
• E7ESH9
• E7EUR5
• E9PFJ6
• Q0VGE5
• Q13341
• Q3KR17
• Q4ZG66
• Q53TG1
• Q6NSG4
• Q92881
• Q96TG3

Gene Name

• SP140

Ensembl ID

• ENST00000343805
• ENSP00000342096
• ENSG00000079263
• ENST00000373645
• ENSP00000362749
• ENST00000392045
• ENSP00000375899
• ENST00000417495
• ENSP00000393618
• ENST00000420434
• ENSP00000398210

Symbol

• LYSP100
• LYSP100
• LYSP100-A
• LYSP100-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
virus perturbation	1
cell type or tissue	0.79
tissue sample	0.66
phenotype	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.3   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.3   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0