You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SP140
Nuclear body protein SP140

Protein Summary
Description
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382). This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343805
  • ENSP00000342096
  • ENSG00000079263
  • ENST00000373645
  • ENSP00000362749
  • ENST00000392045
  • ENSP00000375899
  • ENST00000417495
  • ENSP00000393618
  • ENST00000420434
  • ENSP00000398210

Symbol
  • LYSP100
  • LYSP100
  • LYSP100-A
  • LYSP100-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
cell type or tissue
0.79
tissue sample
0.66
phenotype
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
93.3
4
2
0
1.4
90.5
serum non-albumin protein measurement
1
3
3
87.6
eosinophil count
3
2
3
85.6
eosinophil percentage of leukocytes
2
2
2
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
93.3
0
1.4
90.5
serum non-albumin protein measurement
3
87.6
eosinophil count
3
85.6
eosinophil percentage of leukocytes
2
83.4
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SP140 nuclear body protein
VGNC:2816
100610623
Macaque
SP140 nuclear body protein
710925
Dog
SP140 nuclear body protein
609988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SP140 nuclear body protein
Macaque
SP140 nuclear body protein
Dog
SP140 nuclear body protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13342-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (30)
1 – 10 of 30
SP140L
Tdark
Family:  TF; Epigenetic
Novelty:  0.43376161
Score:  0.775
Data Source:  STRINGDB
DPRX
Tdark
Family:  TF
Novelty:  0.15983197
Score:  0.706
Data Source:  STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
Score:  0.673
Data Source:  STRINGDB
COL24A1
Tbio
Novelty:  0.13795217
Score:  0.658
Data Source:  STRINGDB
FAM91A1
Tbio
Novelty:  0.76982657
Score:  0.652
Data Source:  STRINGDB
SUGCT
Tbio
Family:  Enzyme
Novelty:  0.0075902
Score:  0.651
Data Source:  STRINGDB
NUP210
Tbio
Novelty:  0.00784579
Score:  0.593
Data Source:  STRINGDB
TENT5C
Tbio
Novelty:  0.0581292
Score:  0.58
Data Source:  STRINGDB
PAPSS2
Tbio
Family:  Enzyme
Novelty:  0.01538798
Score:  0.575
Data Source:  STRINGDB
NLRP7
Tbio
Novelty:  0.01301125
Score:  0.571
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.12

PubMed score by year
PubTator Score  10.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: