Tchem SLC14A1 Urea transporter 1

Protein Summary

Description

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q13336
• A8K0P3
• B3KR62
• B3KVX3
• C9EHF2
• Q86VM5

Gene Name

• SLC14A1

Ensembl ID

• ENST00000321925
• ENSP00000318546
• ENSG00000141469
• ENST00000415427
• ENSP00000412309
• ENST00000436407
• ENSP00000390637
• ENST00000586142
• ENSP00000470476
• ENST00000586951
• ENSP00000465702

Symbol

• HUT11
• JK
• RACH1
• UT1
• UTE
• JK
• UT1
• UTE
• HUT11
• RACH1
• RACH2
• UT-B1
• HsT1341

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
gene perturbation	0.75
microRNA	0.61
transcription factor	0.61
transcription factor perturbation	0.54

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc14 Family Of Facilitative Urea Transporters / Urea Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.81   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.81   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0