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Tbio
MTA1
Metastasis-associated protein MTA1

Protein Summary
Description
Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in br ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331320
  • ENSP00000333633
  • ENSG00000182979
  • ENST00000405646
  • ENSP00000384180
  • ENST00000438610
  • ENSP00000393438
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
biological process
0.89
protein domain
0.85
hub protein
0.82
biological term
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.76   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.76   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (42)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (200)
1 – 10 of 200
RBBP7
Tbio
Novelty: 0.02883677
p_int: 1
Score: 0.997
Data Source: BioPlex,STRINGDB
ZNF521
Tbio
Family: TF
Novelty: 0.0227072
p_int: 0.999999892
p_ni: 1.08e-7
p_wrong: 1e-9
Score: 0.828
Data Source: BioPlex,STRINGDB
ZNF423
Tbio
Family: TF
Novelty: 0.02118978
p_int: 0.99999981
p_ni: 1.9e-7
Score: 0.828
Data Source: BioPlex,STRINGDB
ZNF219
Tbio
Family: TF
Novelty: 0.25418994
p_int: 0.99999966
p_ni: 3.4e-7
Score: 0.759
Data Source: BioPlex,STRINGDB
BCL11A
Tbio
Family: TF
Novelty: 0.00588596
p_int: 0.999999568
p_ni: 4.32e-7
Score: 0.884
Data Source: BioPlex,STRINGDB
MBD3L1
Tbio
Novelty: 0.16444958
p_int: 0.999996856
p_ni: 0.000003144
Score: 0.885
Data Source: BioPlex,STRINGDB
TSHZ3
Tbio
Family: TF
Novelty: 0.02767495
p_int: 0.999996448
p_ni: 0.00000355
p_wrong: 2e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
p_int: 0.999991577
p_ni: 0.000008423
Score: 0.999
Data Source: BioPlex,STRINGDB
CDK2AP1
Tbio
Family: Enzyme
Novelty: 0.00794768
p_int: 0.999984463
p_ni: 0.000015538
Score: 0.464
Data Source: BioPlex,STRINGDB
GATAD2B
Tbio
Family: TF
Novelty: 0.07240695
p_int: 0.999968889
p_ni: 0.000031111
Score: 0.995
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  228.76

PubMed score by year
PubTator Score  205.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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