Protein Classes
Protein Summary
Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
- ENST00000218867
- ENSP00000218867
- ENSG00000102683
- A4
- MAM
- DMDA
- SCG3
- 35DAG
- DAGA4
- DMDA1
- LGMD2C
- LGMDR5
- SCARMD2
- gamma-SG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein complex | 0.91 | ||
gene perturbation | 0.9 | ||
trait | 0.86 | ||
tissue sample | 0.62 | ||
small molecule perturbation | 0.61 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.25 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.25 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (12)
KEGG (4)
WikiPathways (8)
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Dilated cardiomyopathy (DCM) | ||||
KEGG | Viral myocarditis | ||||
KEGG | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
KEGG | Hypertrophic cardiomyopathy (HCM) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Dilated cardiomyopathy (DCM) | ||||
Viral myocarditis | ||||
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||||
Hypertrophic cardiomyopathy (HCM) | ||||
Gene Ontology Terms (9)
Components (7)
Processes (2)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (58)
1 – 10 of 58
SGCA
Novelty: 0.00500833
Score: 0.948
Data Source: STRINGDB
DMD
Novelty: 0.00029078
Score: 0.93
Data Source: STRINGDB
SSPN
Novelty: 0.02254936
Score: 0.915
Data Source: STRINGDB
DAG1
Family: Enzyme
Novelty: 0.00185637
Score: 0.869
Data Source: STRINGDB
SGCE
Novelty: 0.00599539
Score: 0.849
Data Source: STRINGDB
SGCB
Novelty: 0.0009261
Score: 0.837
Data Source: STRINGDB
SNTB1
Novelty: 0.07544233
Score: 0.815
Data Source: STRINGDB
UTRN
Novelty: 0.00225431
Score: 0.8
Data Source: STRINGDB
CAV3
Novelty: 0.00250765
Score: 0.79
Data Source: STRINGDB
SNTA1
Novelty: 0.03034237
Score: 0.782
Data Source: STRINGDB
Publication Statistics
PubMed Score 172.25
PubMed score by year
PubTator Score 301.36
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MVREQYTTATEGICIERPENQYVYKIGIYGWRKRCLYLFVLLLLIILVVNLALTIWILKVMWFSPAGMGH
1-70
LCVTKDGLRLEGESEFLFPLYAKEIHSRVDSSLLLQSTQNVTVNARNSEGEVTGRLKVGPKMVEVQNQQF
70-140
QINSNDGKPLFTVDEKEVVVGTDKLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVH
140-210
IQAHAGKIEALSQMDILFHSSDGMLVLDAETVCLPKLVQGTWGPSGSSQSLYEICVCPDGKLYLSVAGVS
210-280
TTCQEHNHICL
280-291
MVREQYTTATEGICIERPENQYVYKIGIYGWRKRCLYLFVLLLLIILVVNLALTIWILKVMWFSPAGMGHLCVTKDGLRLEGESEFLFPLYAKEIHSRVDSSLLLQSTQNVTVNARNSEGEVTGRLKVGPKMVEVQNQQFQINSNDGKPLFTVDEKEVVVGTDKLRVTGPEGALFEHSVETPLVRADPFQDLRLESPTRSLSMDAPRGVHIQAHAGKIEALSQMDILFHSSDGMLVLDAETVCLPKLVQGTWGPSGSSQSLYEICVCPDGKLYLSVAGVSTTCQEHNHICL
Find similar targets by: