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Tbio
IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

Protein Summary
Description
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371795
  • ENSP00000360860
  • ENSG00000152778

Symbol
  • ISG58
  • RI58
  • P58
  • RI58
  • ISG58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.85
PubMedID
0.8
tissue sample
0.63
microRNA
0.61


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 5
VGNC:4716
466152
Macaque
interferon induced protein with tetratricopeptide repeats 5
695796
Dog
interferon induced protein with tetratricopeptide repeats 5
486788
Horse
interferon induced protein with tetratricopeptide repeats 5
VGNC:18947
102147645
Cow
interferon induced protein with tetratricopeptide repeats 5
VGNC:30051
515091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 5
Macaque
interferon induced protein with tetratricopeptide repeats 5
Dog
interferon induced protein with tetratricopeptide repeats 5
Horse
interferon induced protein with tetratricopeptide repeats 5
Cow
interferon induced protein with tetratricopeptide repeats 5
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13325-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (69)
1 – 10 of 69
KCTD6
Tbio
Novelty: 0.43478298
p_int: 0.999867475
p_ni: 0.000132517
p_wrong: 8e-9
Score: 0.336
Data Source: BioPlex,STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.990929872
p_ni: 0.008323744
p_wrong: 0.000746384
Score: 0.241
Data Source: BioPlex,STRINGDB
CRKL
Tbio
Novelty: 0.0051181
p_int: 0.983447191
p_ni: 0.016552809
Score: 0.685
Data Source: BioPlex,STRINGDB
DMD
Tclin
Novelty: 0.00025661
p_int: 0.977309331
p_ni: 0.022690658
p_wrong: 1.1e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.914
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.899
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.864
Data Source: STRINGDB
DDX60
Tbio
Family: Enzyme
Novelty: 0.09487565
Score: 0.853
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.849
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.846
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.26

PubMed score by year
PubTator Score  12.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer