You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

Protein Summary
Description
Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense. Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268). Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420). Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268). Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371795
  • ENSP00000360860
  • ENSG00000152778

Symbol
  • ISG58
  • RI58
  • P58
  • RI58
  • ISG58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.85
PubMedID
0.8
tissue sample
0.63
microRNA
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (69)
1 – 10 of 69
KCTD6
Tbio
Novelty: 0.43478298
p_int: 0.999867475
p_ni: 0.000132517
p_wrong: 8e-9
Score: 0.336
Data Source: BioPlex,STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.990929872
p_ni: 0.008323744
p_wrong: 0.000746384
Score: 0.241
Data Source: BioPlex,STRINGDB
CRKL
Tbio
Novelty: 0.0051181
p_int: 0.983447191
p_ni: 0.016552809
Score: 0.685
Data Source: BioPlex,STRINGDB
DMD
Tclin
Novelty: 0.00025661
p_int: 0.977309331
p_ni: 0.022690658
p_wrong: 1.1e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.01502223
Score: 0.914
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.899
Data Source: STRINGDB
DDX58
Tbio
Family: Enzyme
Novelty: 0.00080099
Score: 0.864
Data Source: STRINGDB
DDX60
Tbio
Family: Enzyme
Novelty: 0.09487565
Score: 0.853
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.849
Data Source: STRINGDB
IFIH1
Tbio
Family: Enzyme
Novelty: 0.00111499
Score: 0.846
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.26

PubMed score by year
PubTator Score  12.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer