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Tbio
CRHR2
Corticotropin-releasing factor receptor 2

Protein Summary
Description
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding differ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341843
  • ENSP00000344304
  • ENSG00000106113
  • ENST00000348438
  • ENSP00000340943
  • ENST00000471646
  • ENSP00000418722
  • ENST00000506074
  • ENSP00000426498

Symbol
  • CRF2R
  • CRH2R
  • CRF2
  • CRFR2
  • CRF-RB
  • HM-CRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.85
protein domain
0.85
biological term
0.67
disease perturbation
0.62
disease
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.13   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 598   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.13   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 598   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
2
1.1
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
89.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
corticotropin releasing hormone receptor 2
VGNC:4322
748363
Macaque
corticotropin releasing hormone receptor 2
697404
Mouse
MGI:894312
12922
Rat
RGD:70547
64680
Dog
corticotropin releasing hormone receptor 2
VGNC:39611
482384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
corticotropin releasing hormone receptor 2
Macaque
corticotropin releasing hormone receptor 2
Mouse
Rat
Dog
corticotropin releasing hormone receptor 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13324-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Metabolism of proteins
Protein-Protein Interactions (176)
1 – 10 of 176
CRH
Tbio
Novelty: 0.000147
Score: 0.999
Data Source: Reactome,STRINGDB
UCN
Tbio
Novelty: 0.00151712
Score: 0.994
Data Source: Reactome,STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.97
Data Source: STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.965
Data Source: STRINGDB
UCN3
Tbio
Novelty: 0.00996251
Score: 0.964
Data Source: Reactome,STRINGDB
UCN2
Tbio
Novelty: 0.00848272
Score: 0.955
Data Source: Reactome,STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.947
Data Source: STRINGDB
MC2R
Tclin
Family: GPCR
Novelty: 0.00485539
Score: 0.946
Data Source: STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00091593
Score: 0.939
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.939
Data Source: STRINGDB
Publication Statistics
PubMed Score  360.13

PubMed score by year
PubTator Score  207.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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