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Tbio
GRB10
Growth factor receptor-bound protein 10

Protein Summary
Description
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335866
  • ENSP00000338543
  • ENSG00000106070
  • ENST00000357271
  • ENSP00000349818
  • ENST00000398810
  • ENSP00000381790
  • ENST00000398812
  • ENSP00000381793
  • ENST00000401949
  • ENSP00000385770
  • ENST00000402497
  • ENSP00000385748
  • ENST00000402578
  • ENSP00000385189
  • ENST00000403097
  • ENSP00000385544
  • ENST00000406641
  • ENSP00000385366
  • ENST00000407526
  • ENSP00000385046
  • ENST00000643299
  • ENSP00000496245
  • ENST00000645075
  • ENSP00000495341

Symbol
  • GRBIR
  • KIAA0207
  • RSS
  • IRBP
  • MEG1
  • GRB-IR
  • Grb-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
hub protein
0.98
disease perturbation
0.97
PubMedID
0.96
kinase
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.42   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.42   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0