Tbio GRB10 Growth factor receptor-bound protein 10

Protein Summary

Description

Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q13322
• A4D258
• A7VJ95
• A8K0E6
• D3DVM9
• O00427
• O00701
• O75222
• Q92606
• Q92907
• Q92948

Gene Name

• GRB10

Ensembl ID

• ENST00000335866
• ENSP00000338543
• ENSG00000106070
• ENST00000357271
• ENSP00000349818
• ENST00000398810
• ENSP00000381790
• ENST00000398812
• ENSP00000381793
• ENST00000401949
• ENSP00000385770
• ENST00000402497
• ENSP00000385748
• ENST00000402578
• ENSP00000385189
• ENST00000403097
• ENSP00000385544
• ENST00000406641
• ENSP00000385366
• ENST00000407526
• ENSP00000385046
• ENST00000643299
• ENSP00000496245
• ENST00000645075
• ENSP00000495341

Symbol

• GRBIR
• KIAA0207
• RSS
• IRBP
• MEG1
• GRB-IR
• Grb-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
hub protein	0.98
disease perturbation	0.97
PubMedID	0.96
kinase	0.88

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Growth Factor Receptor-bound Protein 10

DTO Classes

Protein / Receptor / Growth Factor Receptor-bound Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.42   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.42   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0