GRB10
Growth factor receptor-bound protein 10
Protein Summary
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive ...more
- ENST00000335866
- ENSP00000338543
- ENSG00000106070
- ENST00000357271
- ENSP00000349818
- ENST00000398810
- ENSP00000381790
- ENST00000398812
- ENSP00000381793
- ENST00000401949
- ENSP00000385770
- ENST00000402497
- ENSP00000385748
- ENST00000402578
- ENSP00000385189
- ENST00000403097
- ENSP00000385544
- ENST00000406641
- ENSP00000385366
- ENST00000407526
- ENSP00000385046
- ENST00000643299
- ENSP00000496245
- ENST00000645075
- ENSP00000495341
- GRBIR
- KIAA0207
- RSS
- IRBP
- MEG1
- GRB-IR
- Grb-10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
hub protein | 0.98 | ||
disease perturbation | 0.97 | ||
PubMedID | 0.96 | ||
kinase | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.55 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 420 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 156.55 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 420 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (141)
WDR59
Novelty: 0.22243351
p_int: 0.999999999
p_ni: 1e-9
Score: 0.277
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (77)
Reactome (10)
KEGG (1)
PathwayCommons (8)
WikiPathways (58)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | IRS activation | ||||
Reactome | Insulin receptor signalling cascade | ||||
Reactome | RET signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
IRS activation | ||||
Insulin receptor signalling cascade | ||||
RET signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (3)
Components (4)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 3 | 2 | 1 | 86.1 | ||||
body mass index | 4 | 3 | 4 | 81.2 | |||||
eosinophil count | 2 | 2 | 2 | 74.1 | |||||
fasting blood glucose measurement | 2 | 2 | 2 | 70.4 | |||||
feeling emotionally hurt measurement | 1 | 1 | 0 | 8.3 | 67.1 | ||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 2 | 1 | 86.1 | ||||
body mass index | 4 | 81.2 | |||||
eosinophil count | 2 | 74.1 | |||||
fasting blood glucose measurement | 2 | 70.4 | |||||
feeling emotionally hurt measurement | 0 | 8.3 | 67.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | growth factor receptor bound protein 10 | VGNC:4380 | 463410 | |||||
Macaque | growth factor receptor bound protein 10 | 694786 | ||||||
Mouse | MGI:103232 | 14783 | ||||||
Rat | RGD:1566234 | 498416 | ||||||
Dog | growth factor receptor bound protein 10 | VGNC:51874 | 607755 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | growth factor receptor bound protein 10 | |||||
Macaque | growth factor receptor bound protein 10 | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth factor receptor bound protein 10 | |||||
Publication Statistics
PubMed Score 156.55
PubMed score by year
PubTator Score 103.97
PubTator score by year
Related Publications
Text Mined References (78)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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