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Tbio
GRB10
Growth factor receptor-bound protein 10

Protein Summary
Description
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335866
  • ENSP00000338543
  • ENSG00000106070
  • ENST00000357271
  • ENSP00000349818
  • ENST00000398810
  • ENSP00000381790
  • ENST00000398812
  • ENSP00000381793
  • ENST00000401949
  • ENSP00000385770
  • ENST00000402497
  • ENSP00000385748
  • ENST00000402578
  • ENSP00000385189
  • ENST00000403097
  • ENSP00000385544
  • ENST00000406641
  • ENSP00000385366
  • ENST00000407526
  • ENSP00000385046
  • ENST00000643299
  • ENSP00000496245
  • ENST00000645075
  • ENSP00000495341

Symbol
  • GRBIR
  • KIAA0207
  • RSS
  • IRBP
  • MEG1
  • GRB-IR
  • Grb-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
hub protein
0.98
disease perturbation
0.97
PubMedID
0.96
kinase
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.51   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.51   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
2
90.5
age-related hearing impairment
1
1
0
5.8
62.8
putamen volume
1
1
0
6.1
58.2
waist-hip ratio
1
1
1
53.2
self reported educational attainment
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
90.5
age-related hearing impairment
0
5.8
62.8
putamen volume
0
6.1
58.2
waist-hip ratio
1
53.2
self reported educational attainment
1
52
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 10
VGNC:4380
463410
Macaque
growth factor receptor bound protein 10
694786
Mouse
MGI:103232
14783
Rat
RGD:1566234
498416
Dog
growth factor receptor bound protein 10
VGNC:51874
607755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth factor receptor bound protein 10
Macaque
growth factor receptor bound protein 10
Mouse
Rat
Dog
growth factor receptor bound protein 10
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13322-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (77)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
IRS activation
Reactome
Insulin receptor signalling cascade
Reactome
RET signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
IRS activation
Insulin receptor signalling cascade
RET signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (141)
1 – 10 of 141
WDR59
Tdark
Novelty: 0.22243351
p_int: 0.999999999
p_ni: 1e-9
Score: 0.277
Data Source: BioPlex,STRINGDB
IGF1R
Tclin
Family: Kinase
Novelty: 0.00034532
Score: 0.984
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00048281
Score: 0.978
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.972
Data Source: Reactome,STRINGDB
IRS2
Tbio
Novelty: 0.00164304
Score: 0.97
Data Source: STRINGDB
NEDD4
Tchem
Family: Enzyme
Novelty: 0.00281725
Score: 0.969
Data Source: STRINGDB
INSR
Tclin
Family: Kinase
Novelty: 0.00230617
Score: 0.969
Data Source: Reactome,STRINGDB
GIGYF1
Tdark
Novelty: 0.33031107
Score: 0.966
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.966
Data Source: STRINGDB
IGF1
Tbio
Novelty: 0.00003878
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  153.51

PubMed score by year
PubTator Score  103.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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