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Tchem
ATM
Serine-protein kinase ATM

Protein Summary
Description
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278616
  • ENSP00000278616
  • ENSG00000149311
  • ENST00000452508
  • ENSP00000388058

Symbol
  • AT1
  • ATA
  • ATC
  • ATD
  • ATE
  • ATDC
  • TEL1
  • TELO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
0.99
protein domain
0.99


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5651.91   (req: < 5)
Gene RIFs: 876   (req: <= 3)
Antibodies: 1297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5651.91   (req: >= 5)
Gene RIFs: 876   (req: > 3)
Antibodies: 1297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 100
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
mean corpuscular hemoglobin concentration
2
2
2
92.5
mean corpuscular volume
3
3
3
91.7
mosaic loss of chromosome Y measurement
3
2
3
90.3
platelet count
3
3
3
86.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
mean corpuscular hemoglobin concentration
2
92.5
mean corpuscular volume
3
91.7
mosaic loss of chromosome Y measurement
3
90.3
platelet count
3
86.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATM serine/threonine kinase
VGNC:11264
451530
Macaque
ATM serine/threonine kinase
100427400
Mouse
MGI:107202
11920
Rat
RGD:1593265
300711
Dog
ATM serine/threonine kinase
VGNC:38233
479450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATM serine/threonine kinase
Macaque
ATM serine/threonine kinase
Mouse
Rat
Dog
ATM serine/threonine kinase
Protein Structure (2 Structures, 10 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (94)
Autodegradation of the E3 ubiquitin ligase COP1 (R-HSA-349425)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autodegradation of the E3 ubiquitin ligase COP1
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
Autodegradation of the E3 ubiquitin ligase COP1
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular response to heat stress
Gene Ontology Terms (65)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (773)
1 – 10 of 773
BSG
Tbio
Novelty:  0.0010285
p_int:  0.999703694
p_ni:  0.000296306
Score:  0.176
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.999453496
p_ni:  0.000546504
Data Source:  BioPlex
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.998722317
p_ni:  0.001277683
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.996389559
p_ni:  0.003610441
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.995539998
p_ni:  0.004460002
Data Source:  BioPlex
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
p_int:  0.991659554
p_ni:  0.008340433
p_wrong:  1.3e-8
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.985072571
p_ni:  0.014927429
Data Source:  BioPlex
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
p_int:  0.960986668
p_ni:  0.039013332
Score:  0.194
Data Source:  BioPlex,STRINGDB
CD274
Tclin
Novelty:  0.00013449
p_int:  0.933939845
p_ni:  0.066060154
p_wrong:  1e-9
Score:  0.345
Data Source:  BioPlex,STRINGDB
P2RY8
Tbio
Family:  GPCR
Novelty:  0.05574297
p_int:  0.897345414
p_ni:  0.102654586
Data Source:  BioPlex
Publication Statistics
PubMed Score  5651.91

PubMed score by year
PubTator Score  2255.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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