Protein Summary
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as ...more
- ENST00000278616
- ENSP00000278616
- ENSG00000149311
- ENST00000452508
- ENSP00000388058
- AT1
- ATA
- ATC
- ATD
- ATE
- ATDC
- TEL1
- TELO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
hub protein | 1 | ||
molecular function | 0.99 | ||
protein domain | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5651.91 (req: < 5)
Gene RIFs: 876 (req: <= 3)
Antibodies: 1297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5651.91 (req: >= 5)
Gene RIFs: 876 (req: > 3)
Antibodies: 1297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 60
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 100
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (100)
Protein-Protein Interactions (773)
BSG
Novelty: 0.0010285
p_int: 0.999703694
p_ni: 0.000296306
Score: 0.176
Data Source: BioPlex,STRINGDB
NPY2R
Family: GPCR
Novelty: 0.01177255
p_int: 0.999453496
p_ni: 0.000546504
Data Source: BioPlex
LPAR4
Family: GPCR
Novelty: 0.02200758
p_int: 0.998722317
p_ni: 0.001277683
Data Source: BioPlex
OPRM1
Family: GPCR
Novelty: 0.0003701
p_int: 0.991659554
p_ni: 0.008340433
p_wrong: 1.3e-8
Data Source: BioPlex
EDNRB
Family: GPCR
Novelty: 0.00053875
p_int: 0.960986668
p_ni: 0.039013332
Score: 0.194
Data Source: BioPlex,STRINGDB
CD274
Novelty: 0.00013449
p_int: 0.933939845
p_ni: 0.066060154
p_wrong: 1e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (3)
Downstream (1)
1 – 3 of 3
Pathways (94)
Reactome (47)
KEGG (13)
PathwayCommons (12)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Autodegradation of the E3 ubiquitin ligase COP1 | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular response to heat stress | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Autodegradation of the E3 ubiquitin ligase COP1 | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cellular Senescence | ||||
Cellular response to heat stress | ||||
Viral Interactions (0)
Gene Ontology Terms (65)
Functions (8)
Components (5)
Processes (52)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 3 | 93.4 | |||||
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 92.5 | |||||
mean corpuscular volume | 3 | 3 | 3 | 91.7 | |||||
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 90.3 | |||||
platelet count | 3 | 3 | 3 | 86.9 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
eosinophil count | 3 | 93.4 | |||||
mean corpuscular hemoglobin concentration | 2 | 92.5 | |||||
mean corpuscular volume | 3 | 91.7 | |||||
mosaic loss of chromosome Y measurement | 3 | 90.3 | |||||
platelet count | 3 | 86.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ATM serine/threonine kinase | VGNC:11264 | 451530 | |||||
Macaque | ATM serine/threonine kinase | 100427400 | ||||||
Mouse | MGI:107202 | 11920 | ||||||
Rat | RGD:1593265 | 300711 | ||||||
Dog | ATM serine/threonine kinase | VGNC:38233 | 479450 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ATM serine/threonine kinase | |||||
Macaque | ATM serine/threonine kinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATM serine/threonine kinase | |||||
Publication Statistics
PubMed Score 5651.91
PubMed score by year
PubTator Score 2255.25
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (1093)
GeneRif Annotations (876)
Items per page:
0 of 0
PMID | Year | Title |
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