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Tchem
ATM
Serine-protein kinase ATM

Protein Summary
Description
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278616
  • ENSP00000278616
  • ENSG00000149311
  • ENST00000452508
  • ENSP00000388058

Symbol
  • AT1
  • ATA
  • ATC
  • ATD
  • ATE
  • ATDC
  • TEL1
  • TELO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7040.05   (req: < 5)
Gene RIFs: 876   (req: <= 3)
Antibodies: 1297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7040.05   (req: >= 5)
Gene RIFs: 876   (req: > 3)
Antibodies: 1297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 159
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0