Protein Classes
Protein Summary
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as ...more
- ENST00000278616
- ENSP00000278616
- ENSG00000149311
- ENST00000452508
- ENSP00000388058
- AT1
- ATA
- ATC
- ATD
- ATE
- ATDC
- TEL1
- TELO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
hub protein | 1 | ||
molecular function | 0.99 | ||
protein domain | 0.99 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5491.78 (req: < 5)
Gene RIFs: 876 (req: <= 3)
Antibodies: 1297 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5491.78 (req: >= 5)
Gene RIFs: 876 (req: > 3)
Antibodies: 1297 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 60
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 62
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (62)
1 – 10 of 62
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 3 | 3 | 89.2 | |||||
lymphocyte count | 2 | 2 | 2 | 76.7 | |||||
refractive error measurement | 1 | 1 | 1 | 73.8 | |||||
1 | 2 | 0 | 1.3 | 68.5 | |||||
1 | 1 | 0 | 1.1 | 64.8 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 3 | 89.2 | |||||
lymphocyte count | 2 | 76.7 | |||||
refractive error measurement | 1 | 73.8 | |||||
0 | 1.3 | 68.5 | |||||
0 | 1.1 | 64.8 | |||||
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (94)
Reactome (47)
KEGG (13)
PathwayCommons (12)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 47
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autodegradation of the E3 ubiquitin ligase COP1 | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular response to heat stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autodegradation of the E3 ubiquitin ligase COP1 | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cellular Senescence | ||||
Cellular response to heat stress | ||||
Gene Ontology Terms (65)
Functions (8)
Components (5)
Processes (52)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (773)
1 – 10 of 773
BSG
Novelty: 0.0010285
p_int: 0.999703694
p_ni: 0.000296306
Score: 0.176
Data Source: BioPlex,STRINGDB
NPY2R
Family: GPCR
Novelty: 0.01177255
p_int: 0.999453496
p_ni: 0.000546504
Data Source: BioPlex
LPAR4
Family: GPCR
Novelty: 0.02200758
p_int: 0.998722317
p_ni: 0.001277683
Data Source: BioPlex
OPALIN
Novelty: 0.08221612
p_int: 0.996389559
p_ni: 0.003610441
Data Source: BioPlex
CYB5B
Novelty: 0.09395308
p_int: 0.995539998
p_ni: 0.004460002
Data Source: BioPlex
OPRM1
Family: GPCR
Novelty: 0.0003701
p_int: 0.991659554
p_ni: 0.008340433
p_wrong: 1.3e-8
Data Source: BioPlex
CD70
Novelty: 0.00420393
p_int: 0.985072571
p_ni: 0.014927429
Data Source: BioPlex
EDNRB
Family: GPCR
Novelty: 0.00053875
p_int: 0.960986668
p_ni: 0.039013332
Score: 0.194
Data Source: BioPlex,STRINGDB
CD274
Novelty: 0.00013449
p_int: 0.933939845
p_ni: 0.066060154
p_wrong: 1e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
P2RY8
Family: GPCR
Novelty: 0.05574297
p_int: 0.897345414
p_ni: 0.102654586
Data Source: BioPlex
Publication Statistics
PubMed Score 5491.78
PubMed score by year
PubTator Score 2255.25
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Ortholog Sequence Conservation
PolarG S T Y C
NeutralQ N
BasicK R H
AcidicD E
HydrophobicA V L I P W F M
Find similar targets by:
UniProt Keyword
GWAS Trait