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Tbio
PABPC4
Polyadenylate-binding protein 4

Protein Summary
Description
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stab ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372856
  • ENSP00000361947
  • ENSG00000090621
  • ENST00000372857
  • ENSP00000361948
  • ENST00000372858
  • ENSP00000361949

Symbol
  • APP1
  • PABP4
  • APP1
  • APP-1
  • PABP4
  • iPABP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
virus perturbation
0.94
kinase perturbation
0.91
protein complex
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
3
4
98.3
high density lipoprotein cholesterol measurement
6
4
10
96.7
3
1
0
1.1
86.2
red blood cell distribution width
3
1
3
82.9
mean corpuscular hemoglobin concentration
1
1
1
82.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
98.3
high density lipoprotein cholesterol measurement
10
96.7
0
1.1
86.2
red blood cell distribution width
3
82.9
mean corpuscular hemoglobin concentration
1
82.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein cytoplasmic 4
VGNC:9320
456782
Macaque
poly(A) binding protein cytoplasmic 4
716083
Mouse
MGI:2385206
230721
Rat
RGD:1305015
298510
Dog
poly(A) binding protein cytoplasmic 4 [Source:HGNC Symbol;Acc:HGNC:8557]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
poly(A) binding protein cytoplasmic 4
Macaque
poly(A) binding protein cytoplasmic 4
Mouse
Rat
Dog
poly(A) binding protein cytoplasmic 4 [Source:HGNC Symbol;Acc:HGNC:8557]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13310-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
RNA degradation
KEGG
mRNA surveillance pathway
KEGG
RNA transport
Name
Explore in Pharos
Explore in Source
RNA degradation
mRNA surveillance pathway
RNA transport
Gene Ontology Terms (15)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (160)
1 – 10 of 160
GSPT2
Tbio
Family: Enzyme
Novelty: 0.08140512
p_int: 0.989132121
p_ni: 0.010867879
Score: 0.889
Data Source: BioPlex,STRINGDB
HNRNPDL
Tbio
Novelty: 0.00222179
p_int: 0.952598702
p_ni: 0.047401298
Score: 0.391
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.940022413
p_ni: 0.059977587
Score: 0.529
Data Source: BioPlex,STRINGDB
TRA2A
Tbio
Novelty: 0.04935993
p_int: 0.805583118
p_ni: 0.194416882
Score: 0.457
Data Source: BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty: 0.17313739
p_int: 0.798745216
p_ni: 0.201254784
Data Source: BioPlex
APOBEC3D
Tbio
Novelty: 0.01102619
p_int: 0.773241041
p_ni: 0.226758959
Score: 0.539
Data Source: BioPlex,STRINGDB
PAIP1
Tbio
Novelty: 0.05922084
Score: 0.938
Data Source: STRINGDB
PAIP2
Tbio
Novelty: 0.04418262
Score: 0.931
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.929
Data Source: STRINGDB
ATXN2
Tbio
Novelty: 0.00373116
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.68

PubMed score by year
PubTator Score  10.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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