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Tbio
SKP2
S-phase kinase-associated protein 2

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. This gene encodes a member of the F-box protein family which is characterized by an approximately 4 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274254
  • ENSP00000274254
  • ENSG00000145604
  • ENST00000274255
  • ENSP00000274255
  • ENST00000620197
  • ENSP00000478031

Symbol
  • FBXL1
  • p45
  • FBL1
  • FLB1
  • FBXL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
ligand (protein) perturbation
0.83
small molecule perturbation
0.82
transcription factor binding site profile
0.81
cellular component
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.92   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 616.92   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
1
3
78.2
mean corpuscular hemoglobin concentration
1
1
1
56.9
mean corpuscular volume
1
1
1
34.5
mean reticulocyte volume
1
1
1
30.8
birth weight
1
1
1
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
78.2
mean corpuscular hemoglobin concentration
1
56.9
mean corpuscular volume
1
34.5
mean reticulocyte volume
1
30.8
birth weight
1
18.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S-phase kinase associated protein 2
VGNC:14453
471570
Macaque
S-phase kinase associated protein 2
700617
Mouse
MGI:1351663
27401
Rat
RGD:1562456
294790
Dog
S-phase kinase associated protein 2
VGNC:51910
489228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S-phase kinase associated protein 2
Macaque
S-phase kinase associated protein 2
Mouse
Rat
Dog
S-phase kinase associated protein 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13309-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (102)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 31
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Protein-Protein Interactions (598)
1 – 10 of 598
CKS1B
Tbio
Family: Enzyme
Novelty: 0.00766779
p_int: 0.999999598
p_ni: 4.02e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999998736
p_ni: 0.000001264
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999997093
p_ni: 0.000002907
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMTNL2
Tdark
Novelty: 0.33805653
p_int: 0.999985392
p_ni: 0.000014608
Score: 0.218
Data Source: BioPlex,STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.99996406
p_ni: 0.00003594
Score: 0.991
Data Source: BioPlex,STRINGDB
REC8
Tbio
Novelty: 0.00732742
p_int: 0.999952424
p_ni: 0.000047576
Data Source: BioPlex
RICTOR
Tbio
Novelty: 0.00250734
p_int: 0.99956488
p_ni: 0.00043512
p_wrong: 1e-9
Score: 0.311
Data Source: BioPlex,STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
p_int: 0.999430446
p_ni: 0.000569554
Score: 0.935
Data Source: BioPlex,STRINGDB
CDK3
Tchem
Family: Kinase
Novelty: 0.03380289
p_int: 0.999428911
p_ni: 0.000571058
p_wrong: 3.1e-8
Score: 0.649
Data Source: BioPlex,STRINGDB
TRIM49
Tdark
Novelty: 0.51794727
p_int: 0.998563566
p_ni: 0.001436429
p_wrong: 5e-9
Score: 0.546
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  616.92

PubMed score by year
PubTator Score  397.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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