SKP2
S-phase kinase-associated protein 2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.99 | ||
ligand (protein) perturbation | 0.83 | ||
small molecule perturbation | 0.82 | ||
transcription factor binding site profile | 0.81 | ||
cellular component | 0.79 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Cell Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | ||||
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Cell Cycle | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 2 | 4 | 88.2 | |||||
mean corpuscular volume | 1 | 1 | 1 | 64.4 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 59.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 54.4 | |||||
3 | 2 | 2 | 1.1 | 35 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 88.2 | |||||
mean corpuscular volume | 1 | 64.4 | |||||
mean reticulocyte volume | 1 | 59.9 | |||||
mean corpuscular hemoglobin concentration | 1 | 54.4 | |||||
2 | 1.1 | 35 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | S-phase kinase associated protein 2 | VGNC:14453 | 471570 | |||||
Macaque | S-phase kinase associated protein 2 | 700617 | ||||||
Mouse | MGI:1351663 | 27401 | ||||||
Rat | RGD:1562456 | 294790 | ||||||
Dog | S-phase kinase associated protein 2 | VGNC:51910 | 489228 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | S-phase kinase associated protein 2 | |||||
Macaque | S-phase kinase associated protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | S-phase kinase associated protein 2 | |||||
PMID | Year | Title |
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