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Tchem
GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

Protein Summary
Description
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272644
  • ENSP00000272644
  • ENSG00000144230
  • ENST00000393018
  • ENSP00000376741
  • ENST00000544369
  • ENSP00000442982
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.56
cell type or tissue
0.52
pathway
0.52
tissue sample
0.51
gene perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (374)
GRK2
Tchem
Family:  Kinase
Novelty:  0.00200696
Score:  0.941
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.939
Data Source:  STRINGDB
CYSLTR1
Tclin
Family:  GPCR
Novelty:  0.00337777
Score:  0.937
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.925
Data Source:  STRINGDB
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
Score:  0.923
Data Source:  STRINGDB
LTB4R2
Tchem
Family:  GPCR
Novelty:  0.01094048
Score:  0.921
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.921
Data Source:  STRINGDB
GPR37
Tbio
Family:  GPCR
Novelty:  0.02193644
Score:  0.921
Data Source:  STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
Score:  0.921
Data Source:  STRINGDB
GNG8
Tdark
Novelty:  0.00590503
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
1
1
1
49.2
myeloid white cell count
1
1
1
47.2
lymphocyte count
1
1
1
36
body mass index
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
1
49.2
myeloid white cell count
1
47.2
lymphocyte count
1
36
body mass index
1
2.1
Find similar targets by:
IDG Resources
Genetic Construct
GPR17-Tango
image for GPR17-Tango
Details:
  • Vector:  addgene66336
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR17-Tango
Order Genetic Construct from:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 17
VGNC:10830
100611956
Macaque
G protein-coupled receptor 17
699576
Mouse
MGI:3584514
574402
Rat
RGD:1589785
767613
Dog
G protein-coupled receptor 17
VGNC:41414
100688664
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 17
Macaque
G protein-coupled receptor 17
Mouse
Rat
Dog
G protein-coupled receptor 17
Publication Statistics
PubMed Score 255.22
PubMed score by year
PubTator Score 95.98
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title