Tchem GPR17 Uracil nucleotide/cysteinyl leukotriene receptor

Protein Summary

Description

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Uniprot Accession IDs

• Q13304
• A8K9L0
• B2R9X0
• Q8N5S7
• Q9UDZ6
• Q9UE21
• UDP/CysLT receptor

Gene Name

• GPR17

Ensembl ID

• ENST00000272644
• ENSP00000272644
• ENSG00000144230
• ENST00000393018
• ENSP00000376741
• ENST00000544369
• ENSP00000442982

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.56
cell type or tissue	0.52
pathway	0.52
tissue sample	0.51
gene perturbation	0.49

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leukotriene Receptor / Uracil Nucleotide/cysteinyl Leukotriene Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.86   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.86   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

adenosine triphosphate

GPR17Tchem GPCR

AGONIST pEC50 : 6.3

montelukast

GPR17Tchem GPCR

ANTAGONIST pKi : 9.3

cangrelor

GPR17Tchem GPCR

ANTAGONIST pIC50 : 8.3

Active Ligands (19)

Explore Active Ligands

1 – 10 of 19

LTE₄

GPR17Tchem GPCR

pKd : 8.6

LTC₄

GPR17Tchem GPCR

pEC50 : 9.13

LTD₄

GPR17Tchem GPCR

pKd : 9.3

UDP-galactose

GPR17Tchem GPCR

: 7.6

ASN02563583

GPR17Tchem GPCR

pEC50 : 9.96

ASN04421891

GPR17Tchem GPCR

pEC50 : 8.44

ASN04450772

GPR17Tchem GPCR

pEC50 : 8.93

ASN04885796

GPR17Tchem GPCR

pEC50 : 9.96

ASN06917370

GPR17Tchem GPCR

pEC50 : 9.57

CHEMBL1097652

GPR17Tchem GPCR

pEC50 : 10.44

Protein-Protein Interactions (374)

Explore Interacting Targets

1 – 10 of 374

• See Interactions on String-DB

GRK2

Tchem

Family:  Kinase

Novelty:  0.00200696

Score:  0.941

Data Source:  STRINGDB

SST

Tbio

Novelty:  0.00005944

Score:  0.939

Data Source:  STRINGDB

CYSLTR1

Tclin

Family:  GPCR

Novelty:  0.00337777

Score:  0.937

Data Source:  STRINGDB

GABBR2

Tclin

Family:  GPCR

Novelty:  0.00739771

Score:  0.925

Data Source:  STRINGDB

P2RY12

Tclin

Family:  GPCR

Novelty:  0.00035406

Score:  0.923

Data Source:  STRINGDB

LTB4R2

Tchem

Family:  GPCR

Novelty:  0.01094048

Score:  0.921

Data Source:  STRINGDB

LPAR5

Tchem

Family:  GPCR

Novelty:  0.01883439

Score:  0.921

Data Source:  STRINGDB

GPR37

Tbio

Family:  GPCR

Novelty:  0.02193644

Score:  0.921

Data Source:  STRINGDB

LPAR1

Tchem

Family:  GPCR

Novelty:  0.00318056

Score:  0.921

Data Source:  STRINGDB

GNG8

Tdark

Novelty:  0.00590503

Score:  0.918

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (11)

WikiPathways (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
G alpha (i) signalling events	408 targets	R-HSA-418594
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
G protein-coupled receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chemokine receptor activity	Traceable Author Statement (TAS)	ProtInc
receptor serine/threonine kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1	1	1		57.8
lymphocyte count	EFO_0004587	1	1	1		46.5
protein C measurement	EFO_0004633	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
myeloid white cell count	EFO_0007988	1		57.8
lymphocyte count	EFO_0004587	1		46.5
protein C measurement	EFO_0004633	1		30.2

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer

GWAS Trait Find Similar Targets

No Header	No Header
lymphocyte count
myeloid white cell count
protein C measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype

IDG Resources

Reagents (1)

Genetic Construct

GPR17-Tango

Details:

• Vector:  addgene66336
• Vector backbone:  pcDNA3.1(+)
• Promoter:  CMV
• Tag:  FLAG

Data:

• GPR17-Tango

Order Genetic Construct from:

addgene

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	G protein-coupled receptor 17	VGNC:10830	100611956
Macaque	G protein-coupled receptor 17		699576
Mouse	G protein-coupled receptor 17	MGI:3584514	574402
Rat	G protein-coupled receptor 17	RGD:1589785	767613
Dog	G protein-coupled receptor 17	VGNC:41414	100688664

Species	Name	OMA	EggNOG	Inparanoid
Chimp	G protein-coupled receptor 17
Macaque	G protein-coupled receptor 17
Mouse	G protein-coupled receptor 17
Rat	G protein-coupled receptor 17
Dog	G protein-coupled receptor 17

Publication Statistics

PubMed Score 206.86

PubMed score by year

Reset Zoom

PubTator Score 95.98

PubTator score by year

Reset Zoom

Patents

Patents by year

Reset Zoom

Related Publications

Text Mined References (25)

GeneRif Annotations (16)

Items per page:

10

0 of 0

PMID	Year	Title