GPR17
Uracil nucleotide/cysteinyl leukotriene receptor
Protein Summary
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
- ENST00000272644
- ENSP00000272644
- ENSG00000144230
- ENST00000393018
- ENSP00000376741
- ENST00000544369
- ENSP00000442982
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.56 | ||
cell type or tissue | 0.52 | ||
pathway | 0.52 | ||
tissue sample | 0.51 | ||
gene perturbation | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 255.22 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 255.22 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 19
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (19)
Protein-Protein Interactions (374)
Nearest Tclin Targets
Pathways (13)
Reactome (11)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Eicosanoid ligand-binding receptors | ||||
Reactome | G alpha (i) signalling events | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Eicosanoid ligand-binding receptors | ||||
G alpha (i) signalling events | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
protein C measurement | 1 | 1 | 1 | 49.2 | |||||
myeloid white cell count | 1 | 1 | 1 | 47.2 | |||||
lymphocyte count | 1 | 1 | 1 | 36 | |||||
body mass index | 1 | 1 | 1 | 2.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
protein C measurement | 1 | 49.2 | |||||
myeloid white cell count | 1 | 47.2 | |||||
lymphocyte count | 1 | 36 | |||||
body mass index | 1 | 2.1 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Genetic Construct
GPR17-Tango
Details:
- Vector: addgene66336
- Vector backbone: pcDNA3.1(+)
- Promoter: CMV
- Tag: FLAG
Data:
- GPR17-Tango
Order Genetic Construct from:
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 17 | VGNC:10830 | 100611956 | |||||
Macaque | G protein-coupled receptor 17 | 699576 | ||||||
Mouse | MGI:3584514 | 574402 | ||||||
Rat | RGD:1589785 | 767613 | ||||||
Dog | G protein-coupled receptor 17 | VGNC:41414 | 100688664 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 17 | |||||
Macaque | G protein-coupled receptor 17 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein-coupled receptor 17 | |||||
Publication Statistics
PubMed Score 255.22
PubMed score by year
PubTator Score 95.98
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (25)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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