Tchem GPR17 Uracil nucleotide/cysteinyl leukotriene receptor

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Leukotriene Receptor / Uracil Nucleotide/cysteinyl Leukotriene Receptor

Protein Summary

Description

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.

Uniprot Accession IDs

• Q13304
• A8K9L0
• B2R9X0
• Q8N5S7
• Q9UDZ6
• Q9UE21
• UDP/CysLT receptor

Gene Name

• GPR17

Ensembl ID

• ENST00000272644
• ENSP00000272644
• ENSG00000144230
• ENST00000393018
• ENSP00000376741
• ENST00000544369
• ENSP00000442982

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.56
cell type or tissue	0.52
pathway	0.52
tissue sample	0.51
gene perturbation	0.49

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.26   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

adenosine triphosphate

GPR17Tchem GPCR

AGONIST EC50 : 7.43

cangrelor

GPR17Tchem GPCR

IC50 : 8.92

montelukast

GPR17Tchem GPCR

IC50 : 7.21

Active Ligands (12)

Explore Active Ligands

1 – 10 of 12

LTE₄

GPR17Tchem GPCR

EC50 : 9.51

LTC₄

GPR17Tchem GPCR

EC50 : 9.13

LTD₄

GPR17Tchem GPCR

EC50 : 9.2

UDP-galactose

GPR17Tchem GPCR

EC50 : 7.17

CHEMBL295718

GPR17Tchem GPCR

EC50 : 7.69

CHEMBL3132880

GPR17Tchem GPCR

EC50 : 7.87

CHEMBL31344

GPR17Tchem GPCR

EC50 : 8.2

ASN02563583

GPR17Tchem GPCR

EC50 : 9.96

ASN04421891

GPR17Tchem GPCR

EC50 : 8.44

ASN04450772

GPR17Tchem GPCR

EC50 : 8.93

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	G protein-coupled receptor 17	VGNC:10830	100611956
Macaque	G protein-coupled receptor 17		699576
Mouse	G protein-coupled receptor 17	MGI:3584514	574402
Rat	G protein-coupled receptor 17	RGD:1589785	767613
Dog	G protein-coupled receptor 17	VGNC:41414	100688664

Species	Name	OMA	EggNOG	Inparanoid
Chimp	G protein-coupled receptor 17
Macaque	G protein-coupled receptor 17
Mouse	G protein-coupled receptor 17
Rat	G protein-coupled receptor 17
Dog	G protein-coupled receptor 17

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q13304-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)

Reactome (11)

WikiPathways (2)

Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Reactome	Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396

Name	Explore in Pharos	Explore in Source
Class A/1 (Rhodopsin-like receptors)	323 targets	R-HSA-373076
Eicosanoid ligand-binding receptors	15 targets	R-HSA-391903
G alpha (i) signalling events	408 targets	R-HSA-418594
G alpha (q) signalling events	219 targets	R-HSA-416476
GPCR downstream signalling	1152 targets	R-HSA-388396

Gene Ontology Terms (10)

Functions (3)

Components (2)

Processes (5)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
G protein-coupled receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chemokine receptor activity	Traceable Author Statement (TAS)	ProtInc
receptor serine/threonine kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (374)

Explore Interacting Targets

1 – 10 of 374

• See Interactions on String-DB

GRK2

Tchem

Family: Kinase

Novelty: 0.00200696

Score: 0.941

Data Source: STRINGDB

SST

Tbio

Novelty: 0.00005944

Score: 0.939

Data Source: STRINGDB

CYSLTR1

Tclin

Family: GPCR

Novelty: 0.00337777

Score: 0.937

Data Source: STRINGDB

GABBR2

Tclin

Family: GPCR

Novelty: 0.00739771

Score: 0.925

Data Source: STRINGDB

P2RY12

Tclin

Family: GPCR

Novelty: 0.00035406

Score: 0.923

Data Source: STRINGDB

LTB4R2

Tchem

Family: GPCR

Novelty: 0.01094048

Score: 0.921

Data Source: STRINGDB

LPAR5

Tchem

Family: GPCR

Novelty: 0.01883439

Score: 0.921

Data Source: STRINGDB

GPR37

Tbio

Family: GPCR

Novelty: 0.02193644

Score: 0.921

Data Source: STRINGDB

LPAR1

Tchem

Family: GPCR

Novelty: 0.00318056

Score: 0.921

Data Source: STRINGDB

GNG8

Tdark

Novelty: 0.00590503

Score: 0.918

Data Source: STRINGDB

Publication Statistics

PubMed Score  195.26

PubMed score by year

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PubTator Score  95.98

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Receptor
Reference proteome
Transducer

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
hematopoietic system phenotype
immune system phenotype
mortality/aging
nervous system phenotype