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Tchem
GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

Protein Summary
Description
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272644
  • ENSP00000272644
  • ENSG00000144230
  • ENST00000393018
  • ENSP00000376741
  • ENST00000544369
  • ENSP00000442982
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.56
cell type or tissue
0.52
pathway
0.52
tissue sample
0.51
gene perturbation
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 255.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3