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Tbio
KCNAB2
Voltage-gated potassium channel subunit beta-2

Protein Summary
Description
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164247
  • ENSP00000164247
  • ENSG00000069424
  • ENST00000341524
  • ENSP00000340824
  • ENST00000352527
  • ENSP00000318772
  • ENST00000378083
  • ENSP00000367323
  • ENST00000378092
  • ENSP00000367332
  • ENST00000378097
  • ENSP00000367337
  • ENST00000458166
  • ENSP00000396167
  • ENST00000602612
  • ENSP00000473602

Symbol
  • KCNA2B
  • KCNK2
  • AKR6A5
  • KCNA2B
  • HKvbeta2
  • KV-BETA-2
  • HKvbeta2.1
  • HKvbeta2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.87
transcription factor
0.82
gene perturbation
0.74
PubMedID
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily A regulatory beta subunit 2
702448
Mouse
MGI:109239
16498
Rat
RGD:61828
29738
Dog
potassium voltage-gated channel subfamily A regulatory beta subunit 2
VGNC:42234
489626
Horse
potassium voltage-gated channel subfamily A regulatory beta subunit 2
VGNC:19264
100052362
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily A regulatory beta subunit 2
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A regulatory beta subunit 2
Horse
potassium voltage-gated channel subfamily A regulatory beta subunit 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13303-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neuronal System
Reactome
Neutrophil degranulation
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neuronal System
Neutrophil degranulation
Potassium Channels
Protein-Protein Interactions (201)
1 – 10 of 201
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
p_int: 0.999999999
p_ni: 1e-9
Score: 0.555
Data Source: BioPlex,Reactome,STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
p_int: 0.999999708
p_ni: 2.92e-7
Score: 0.266
Data Source: BioPlex,Reactome,STRINGDB
CCAR2
Tbio
Novelty: 0.07397743
p_int: 0.999043987
p_ni: 0.000956013
Score: 0.692
Data Source: BioPlex,STRINGDB
KCNA5
Tclin
Family: IC
Novelty: 0.00182891
p_int: 0.998612396
p_ni: 0.001387604
Score: 0.986
Data Source: BioPlex,STRINGDB
TNNC2
Tbio
Novelty: 0.07759506
p_int: 0.998533181
p_ni: 0.000001571
p_wrong: 0.001465248
Score: 0.284
Data Source: BioPlex,STRINGDB
MFAP4
Tbio
Novelty: 0.02023782
p_int: 0.99545809
p_ni: 0.00454191
Data Source: BioPlex
KCNA6
Tclin
Family: IC
Novelty: 18.19090909
p_int: 0.954293242
p_ni: 0.045706674
p_wrong: 8.3e-8
Score: 0.701
Data Source: BioPlex,STRINGDB
HAO1
Tchem
Family: Enzyme
Novelty: 0.00054723
p_int: 0.937255024
p_ni: 0.062744847
p_wrong: 1.28e-7
Score: 0.878
Data Source: BioPlex,STRINGDB
KCNA10
Tclin
Family: IC
Novelty: 0.05708808
p_int: 0.860565913
p_ni: 0.139434087
Score: 0.965
Data Source: BioPlex,STRINGDB
KCNA2
Tclin
Family: IC
Novelty: 0.00164601
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.83

PubMed score by year
PubTator Score  24.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer