Tbio KCNAB2 Voltage-gated potassium channel subunit beta-2

Protein Summary

Description

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q13303
• A0AVM9
• A8K1A4
• B0AZR7
• O43659
• Q2YD85
• Q5TG82
• Q5TG83
• Q6ZNE4
• Q99411

Gene Name

• KCNAB2

Ensembl ID

• ENST00000164247
• ENSP00000164247
• ENSG00000069424
• ENST00000341524
• ENSP00000340824
• ENST00000352527
• ENSP00000318772
• ENST00000378083
• ENSP00000367323
• ENST00000378092
• ENSP00000367332
• ENST00000378097
• ENSP00000367337
• ENST00000458166
• ENSP00000396167
• ENST00000602612
• ENSP00000473602

Symbol

• KCNA2B
• KCNK2
• AKR6A5
• KCNA2B
• HKvbeta2
• KV-BETA-2
• HKvbeta2.1
• HKvbeta2.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
disease perturbation	0.87
transcription factor	0.82
gene perturbation	0.74
PubMedID	0.74

Protein Classes

DTO Classes

Protein / Ion Channel / Voltage-gated Potassium Channel -Subunit (Kv) Family / Voltage-gated Potassium Channel Subunit Beta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.24   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.24   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0