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Tbio
SLAMF1
Signaling lymphocytic activation molecule

Protein Classes
Protein Summary
Description
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302035
  • ENSP00000306190
  • ENSG00000117090
  • ENST00000538290
  • ENSP00000438406

Symbol
  • SLAM
  • SLAM
  • CD150
  • CDw150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.67
gene perturbation
0.65
tissue sample
0.65
cell line
0.64
cellular component
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 914.23   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 923   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 914.23   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 923   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
73.9
cognitive decline measurement
1
1
1
40.1
memory performance
1
1
1
40.1
eosinophil percentage of leukocytes
1
1
1
28.7
1
1
0
1.1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
73.9
cognitive decline measurement
1
40.1
memory performance
1
40.1
eosinophil percentage of leukocytes
1
28.7
0
1.1
3.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signaling lymphocytic activation molecule family member 1
VGNC:1549
457436
Macaque
signaling lymphocytic activation molecule family member 1
719747
Mouse
MGI:1351314
27218
Rat
RGD:1560634
498286
Dog
signaling lymphocytic activation molecule family member 1
VGNC:46206
403642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signaling lymphocytic activation molecule family member 1
Macaque
signaling lymphocytic activation molecule family member 1
Mouse
Rat
Dog
signaling lymphocytic activation molecule family member 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13291-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (201)
1 – 10 of 201
CNTNAP3
Tdark
Novelty: 0.22791524
p_int: 0.998283102
p_ni: 0.001716897
p_wrong: 1e-9
Data Source: BioPlex
ADGRV1
Tbio
Family: GPCR
Novelty: 0.01398129
p_int: 0.998277474
p_ni: 0.001722526
Data Source: BioPlex
RTCA
Tbio
Family: Enzyme
Novelty: 0.03086235
p_int: 0.998211061
p_ni: 0.001663851
p_wrong: 0.000125087
Score: 0.177
Data Source: BioPlex,STRINGDB
NKIRAS1
Tbio
Family: Enzyme
Novelty: 0.11289799
p_int: 0.997895064
p_ni: 0.000033979
p_wrong: 0.002070957
Score: 0.177
Data Source: BioPlex,STRINGDB
FUT11
Tbio
Family: Enzyme
Novelty: 0.16098097
p_int: 0.997609393
p_ni: 0.002390344
p_wrong: 2.62e-7
Data Source: BioPlex
CERCAM
Tdark
Family: Enzyme
Novelty: 0.33392502
p_int: 0.995027138
p_ni: 0.004972862
Data Source: BioPlex
ADAMTS2
Tbio
Family: Enzyme
Novelty: 0.00852208
p_int: 0.994154883
p_ni: 0.005844974
p_wrong: 1.43e-7
Data Source: BioPlex
ITGA7
Tbio
Novelty: 0.01243073
p_int: 0.994101359
p_ni: 0.005898641
Data Source: BioPlex
CPE
Tbio
Family: Enzyme
Novelty: 0.00197792
p_int: 0.993809087
p_ni: 0.006189576
p_wrong: 0.000001337
Score: 0.175
Data Source: BioPlex,STRINGDB
D2HGDH
Tbio
Family: Enzyme
Novelty: 0.04618268
p_int: 0.993132086
p_ni: 0.00686245
p_wrong: 0.000005464
Data Source: BioPlex
Publication Statistics
PubMed Score  914.23

PubMed score by year
PubTator Score  580.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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