Tbio SLAMF1 Signaling lymphocytic activation molecule

Protein Summary

Description

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Mediates IL-2-independent proliferation of activated T-cells during immune responses and induces IFN-gamma production (By similarity). Downstreaming signaling involves INPP5D, DOK1 and DOK2 leading to inhibited IFN-gamma production in T-cells, and PRKCQ, BCL10 and NFKB1 leading to increased T-cell activation and Th2 cytokine production (By similarity). Promotes T-cell receptor-induced IL-4 secretion by CD4(+) cells (By similarity). Inhibits antigen receptor-mediated production of IFN-gamma, but not IL-2, in CD4(-)/CD8(-) T-cells (By similarity). Required for IL-4 production by germinal centers T follicular helper (T(Fh))cells (By similarity). May inhibit CD40-induced signal transduction in monocyte-derived dendritic cells (PubMed:16317102). May play a role in allergic responses and may regulate allergen-induced Th2 cytokine and Th1 cytokine secretion (By similarity). In conjunction with SLAMF6 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage. Involved in the peripheral differentiation of indifferent natural killer T (iNKT) cells toward a regulatory NKT2 type (By similarity). In macrophages involved in down-regulation of IL-12, TNF-alpha and nitric oxide in response to lipopolysaccharide (LPS) (By similarity). In B-cells activates the ERK signaling pathway independently of SH2D1A but implicating both, SYK and INPP5D, and activates Akt signaling dependent on SYK and SH2D1A (By similarity). In B-cells also activates p38 MAPK and JNK1 and JNK2 (PubMed:20231852). In conjunction with CD84/SLAMF5 and SLAMF6 may be a negative regulator of the humoral immune response (By similarity). Involved in innate immune response against Gram-negative bacteria in macrophages; probably recognizes OmpC and/or OmpF on the bacterial surface, regulates phagosome maturation and recruitment of the PI3K complex II (PI3KC3-C2) leading to accumulation of PdtIns(3)P and NOX2 activity in the phagosomes (PubMed:20818396). (Microbial infection) Acts as a receptor for Measles virus; also including isoform 4.

Uniprot Accession IDs

• Q13291
• Q5W172
• Q9HBE8
• W0HKK7

Gene Name

• SLAMF1

Ensembl ID

• ENST00000302035
• ENSP00000306190
• ENSG00000117090
• ENST00000538290
• ENSP00000438406

Symbol

• SLAM
• SLAM
• CD150
• CDw150

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.67
gene perturbation	0.65
tissue sample	0.65
cell line	0.64
cellular component	0.58

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Signaling Lymphocytic Activation Molecule

Protein / Signaling Molecule / Signaling Lymphocytic Activation Molecule

Protein / Receptor / Cytokine Receptor / Immunoglobulin Receptor Superfamily / Signaling Lymphocytic Activation Molecule

Protein / Defense/immunity Protein / Immunoglobulin Receptor Superfamily / Signaling Lymphocytic Activation Molecule

Protein / Cell Adhesion Molecule / Signaling Lymphocytic Activation Molecule

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 949.05   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 923   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 949.05   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 923   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (201)

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1 – 10 of 201

• See Interactions on String-DB

CNTNAP3

Tbio

Novelty:  0.22791524

p_int:  0.998283102

p_ni:  0.001716897

p_wrong:  1e-9

Data Source:  BioPlex

ADGRV1

Tbio

Family:  GPCR

Novelty:  0.01398129

p_int:  0.998277474

p_ni:  0.001722526

Data Source:  BioPlex

RTCA

Tbio

Family:  Enzyme

Novelty:  0.03086235

p_int:  0.998211061

p_ni:  0.001663851

p_wrong:  0.000125087

Score:  0.177

Data Source:  BioPlex,STRINGDB

NKIRAS1

Tbio

Family:  Enzyme

Novelty:  0.11289799

p_int:  0.997895064

p_ni:  0.000033979

p_wrong:  0.002070957

Score:  0.177

Data Source:  BioPlex,STRINGDB

FUT11

Tbio

Family:  Enzyme

Novelty:  0.16098097

p_int:  0.997609393

p_ni:  0.002390344

p_wrong:  2.62e-7

Data Source:  BioPlex

CERCAM

Tdark

Family:  Enzyme

Novelty:  0.33392502

p_int:  0.995027138

p_ni:  0.004972862

Data Source:  BioPlex

ADAMTS2

Tbio

Family:  Enzyme

Novelty:  0.00852208

p_int:  0.994154883

p_ni:  0.005844974

p_wrong:  1.43e-7

Data Source:  BioPlex

ITGA7

Tbio

Novelty:  0.01243073

p_int:  0.994101359

p_ni:  0.005898641

Data Source:  BioPlex

CPE

Tbio

Family:  Enzyme

Novelty:  0.00197792

p_int:  0.993809087

p_ni:  0.006189576

p_wrong:  0.000001337

Score:  0.175

Data Source:  BioPlex,STRINGDB

D2HGDH

Tbio

Family:  Enzyme

Novelty:  0.04618268

p_int:  0.993132086

p_ni:  0.00686245

p_wrong:  0.000005464

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Measles	138 targets	path:hsa05162

Name	Explore in Pharos	Explore in Source
Measles	138 targets	path:hsa05162

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (4)

Components (4)

Processes (13)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
antigen binding	Traceable Author Statement (TAS)	ProtInc
transmembrane signaling receptor activity	Traceable Author Statement (TAS)	ProtInc
virus receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (7)

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1 – 5 of 7

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	2	3	0	1.1	78.3
eosinophil count	EFO_0004842	2	2	2		74.4
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		57.3
serum IgM measurement	EFO_0004993	1	1	1		30.2
cognitive decline measurement	EFO_0007710	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 7

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	0	1.1	78.3
eosinophil count	EFO_0004842	2		74.4
eosinophil percentage of leukocytes	EFO_0007991	1		57.3
serum IgM measurement	EFO_0004993	1		30.2
cognitive decline measurement	EFO_0007710	1		15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Adaptive immunity
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction

GWAS Trait Find Similar Targets

No Header	No Header
cognitive decline measurement
eosinophil count
eosinophil percentage of leukocytes
memory performance
mosquito bite reaction itch intensity measurement
multiple sclerosis
serum IgM measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	signaling lymphocytic activation molecule family member 1	VGNC:1549	457436
Macaque	signaling lymphocytic activation molecule family member 1		719747
Mouse	signaling lymphocytic activation molecule family member 1	MGI:1351314	27218
Rat	signaling lymphocytic activation molecule family member 1	RGD:1560634	498286
Dog	signaling lymphocytic activation molecule family member 1	VGNC:46206	403642

Species	Name	OMA	EggNOG	Inparanoid
Chimp	signaling lymphocytic activation molecule family member 1
Macaque	signaling lymphocytic activation molecule family member 1
Mouse	signaling lymphocytic activation molecule family member 1
Rat	signaling lymphocytic activation molecule family member 1
Dog	signaling lymphocytic activation molecule family member 1

Publication Statistics

PubMed Score 949.05

PubMed score by year

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PubTator Score 580.62

PubTator score by year

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Related Publications

Text Mined References (82)

GeneRif Annotations (46)

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10

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PMID	Year	Title