Tchem NR5A1 Steroidogenic factor 1

Protein Summary

Description

Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13285
• O15196
• Q5T6F5
• SF-1

Gene Name

• NR5A1

Ensembl ID

• ENST00000373588
• ENSP00000362690
• ENSG00000136931

Symbol

• AD4BP
• FTZF1
• SF1
• ELP
• SF1
• FTZ1
• POF7
• SF-1
• AD4BP
• FTZF1
• SPGF8
• SRXX4
• SRXY3
• hSF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
hub protein	0.9
protein domain	0.85
biological process	0.84
biological term	0.8

Protein Classes

PANTHER Classes

Protein / ... / C4 Zinc Finger Nuclear Receptor / Steroidogenic Factor 1

DTO Classes

Protein / Nuclear Receptor / Fushi Tarazu F1-like Receptors / Steroidogenic Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1467.83   (req: < 5)

Gene RIFs: 211   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1467.83   (req: >= 5)

Gene RIFs: 211   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0