Protein Classes
Protein Summary
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a mono ...more
- ENST00000373588
- ENSP00000362690
- ENSG00000136931
- AD4BP
- FTZF1
- SF1
- ELP
- SF1
- FTZ1
- POF7
- SF-1
- AD4BP
- FTZF1
- SPGF8
- SRXX4
- SRXY3
- hSF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
hub protein | 0.9 | ||
protein domain | 0.85 | ||
biological process | 0.84 | ||
biological term | 0.8 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 885.45 (req: < 5)
Gene RIFs: 175 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 885.45 (req: >= 5)
Gene RIFs: 175 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 1 | 1 | 1 | 47.6 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 1 | 47.6 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | nuclear receptor subfamily 5 group A member 1 | 694183 | ||||||
Mouse | MGI:1346833 | 26423 | ||||||
Rat | RGD:68350 | 83826 | ||||||
Dog | nuclear receptor subfamily 6 group A member 1 | VGNC:49931 | 609642 | |||||
Horse | nuclear receptor subfamily 5 group A member 1 | VGNC:49505 | 100033902 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | nuclear receptor subfamily 5 group A member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nuclear receptor subfamily 6 group A member 1 | |||||
Horse | nuclear receptor subfamily 5 group A member 1 | |||||
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (15)
Reactome (11)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of proteins | ||||
Nuclear Receptor transcription pathway | ||||
Gene Ontology Terms (38)
Functions (14)
Components (3)
Processes (21)
Items per page:
10
1 – 10 of 14
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (150)
1 – 10 of 150
NR0B1
Family: NR
Novelty: 0.00166563
Score: 0.983
Data Source: STRINGDB
UBE2I
Novelty: 0.00267883
Score: 0.967
Data Source: Reactome,STRINGDB
PIAS1
Family: TF
Novelty: 0.00987743
Score: 0.942
Data Source: STRINGDB
SUMO1
Novelty: 0.00137629
Score: 0.937
Data Source: Reactome,STRINGDB
FOXL2
Family: TF
Novelty: 0.00224046
Score: 0.936
Data Source: STRINGDB
SUMO2
Novelty: 0.00366833
Score: 0.932
Data Source: Reactome,STRINGDB
NRIP1
Novelty: 0.00551568
Score: 0.912
Data Source: STRINGDB
PIAS3
Family: TF
Novelty: 0.01380668
Score: 0.902
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.00852082
Score: 0.9
Data Source: STRINGDB
SOX9
Family: TF
Novelty: 0.00047439
Score: 0.891
Data Source: STRINGDB
Publication Statistics
PubMed Score 885.45
PubMed score by year
PubTator Score 607.72
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword