Tchem NR5A1 Steroidogenic factor 1

Protein Classes

PANTHER Classes

Protein / ... / C4 Zinc Finger Nuclear Receptor / Steroidogenic Factor 1

Protein Summary

Description

Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13285
• O15196
• Q5T6F5
• SF-1

Gene Name

• NR5A1

Ensembl ID

• ENST00000373588
• ENSP00000362690
• ENSG00000136931

Symbol

• AD4BP
• FTZF1
• SF1
• ELP
• SF1
• FTZ1
• POF7
• SF-1
• AD4BP
• FTZF1
• SPGF8
• SRXX4
• SRXY3
• hSF-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
hub protein	0.9
protein domain	0.85
biological process	0.84
biological term	0.8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.38   (req: < 5)

Gene RIFs: 175   (req: <= 3)

Antibodies: 377   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 937.38   (req: >= 5)

Gene RIFs: 175   (req: > 3)

Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (5)

Explore Active Ligands

1 – 5 of 5

CHEMBL384424,CHEMBL385911

NR5A1Tchem NR

EC50: 8

CHEMBL384153

NR5A1Tchem NR

EC50: 7.37

CHEMBL216179

NR5A1Tchem NR

EC50: 7.96

CHEMBL425623

NR5A1Tchem NR

EC50: 7.52

CHEMBL214414

NR5A1Tchem NR

EC50: 7.85

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (15)

Reactome (11)

KEGG (2)

WikiPathways (2)

Developmental Biology (R-HSA-1266738)

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Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Nuclear Receptor transcription pathway	53 targets	R-HSA-383280

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Metabolism of proteins	2050 targets	R-HSA-392499
Nuclear Receptor transcription pathway	53 targets	R-HSA-383280

Gene Ontology Terms (38)

Functions (14)

Components (3)

Processes (21)

Items per page:

10

1 – 10 of 14

GO Term	Evidence	Assigned by
DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
nuclear receptor activity	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
phospholipid binding	Inferred from Direct Assay (IDA)	UniProtKB
RNA polymerase II regulatory region sequence-specific DNA binding	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
sequence-specific DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	Inferred from Direct Assay (IDA)	UniProtKB
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
transcription regulatory region sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
chromatin binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
RNA polymerase II distal enhancer sequence-specific DNA binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

NR0B1

Tbio

Family: NR

Novelty: 0.00171069

Score: 0.983

Data Source: STRINGDB

UBE2I

Tbio

Novelty: 0.00316288

Score: 0.967

Data Source: Reactome,STRINGDB

PIAS1

Tbio

Family: TF

Novelty: 0.01153358

Score: 0.942

Data Source: STRINGDB

SUMO1

Tbio

Novelty: 0.00169202

Score: 0.937

Data Source: Reactome,STRINGDB

FOXL2

Tbio

Family: TF

Novelty: 0.00136796

Score: 0.936

Data Source: STRINGDB

SUMO2

Tbio

Novelty: 0.00437464

Score: 0.932

Data Source: Reactome,STRINGDB

NRIP1

Tbio

Novelty: 0.00621822

Score: 0.912

Data Source: STRINGDB

PIAS3

Tbio

Family: TF

Novelty: 0.01507171

Score: 0.902

Data Source: STRINGDB

MED1

Tbio

Family: Enzyme

Novelty: 0.01259825

Score: 0.9

Data Source: STRINGDB

SOX9

Tbio

Family: TF

Novelty: 0.00058844

Score: 0.891

Data Source: STRINGDB

Publication Statistics

PubMed Score  937.38

PubMed score by year

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PubTator Score  607.72

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRF

1-70

QKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVL

70-140

PPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLP

140-210

YGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWA

210-280

RRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLR

280-350

AQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL

350-420

LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

420-461

MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

Find similar targets by:

Uniprot Keyword

3D-structure
Acetylation
Activator
Complete proteome
Disease mutation
DNA-binding
Isopeptide bond
Lipid-binding
Metal-binding
Nucleus