Protein Summary
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a mono ...more
- ENST00000373588
- ENSP00000362690
- ENSG00000136931
- AD4BP
- FTZF1
- SF1
- ELP
- SF1
- FTZ1
- POF7
- SF-1
- AD4BP
- FTZF1
- SPGF8
- SRXX4
- SRXY3
- hSF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
hub protein | 0.9 | ||
protein domain | 0.85 | ||
biological process | 0.84 | ||
biological term | 0.8 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 908.16 (req: < 5)
Gene RIFs: 175 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 908.16 (req: >= 5)
Gene RIFs: 175 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 16
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (16)
Protein-Protein Interactions (150)
Nearest Tclin Targets
Pathways (15)
Reactome (11)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of proteins | ||||
Nuclear Receptor transcription pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (14)
Components (3)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 2 | 2 | 2 | 76 | |||||
platelet crit | 2 | 2 | 2 | 74.5 | |||||
alcohol consumption measurement | 1 | 1 | 1 | 21.5 | |||||
myeloid white cell count | 1 | 1 | 1 | 17.6 | |||||
leukocyte count | 1 | 1 | 1 | 17 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 2 | 76 | |||||
platelet crit | 2 | 74.5 | |||||
alcohol consumption measurement | 1 | 21.5 | |||||
myeloid white cell count | 1 | 17.6 | |||||
leukocyte count | 1 | 17 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | nuclear receptor subfamily 5 group A member 1 | 694183 | ||||||
Mouse | MGI:1346833 | 26423 | ||||||
Rat | RGD:68350 | 83826 | ||||||
Dog | nuclear receptor subfamily 6 group A member 1 | VGNC:49931 | 609642 | |||||
Horse | nuclear receptor subfamily 5 group A member 1 | VGNC:49505 | 100033902 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | nuclear receptor subfamily 5 group A member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nuclear receptor subfamily 6 group A member 1 | |||||
Horse | nuclear receptor subfamily 5 group A member 1 | |||||
Publication Statistics
PubMed Score 908.16
PubMed score by year
PubTator Score 607.72
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (223)
GeneRif Annotations (175)
Items per page:
0 of 0
PMID | Year | Title |
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