Protein Classes
Protein Summary
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a mono ...more
- ENST00000373588
- ENSP00000362690
- ENSG00000136931
- AD4BP
- FTZF1
- SF1
- ELP
- SF1
- FTZ1
- POF7
- SF-1
- AD4BP
- FTZF1
- SPGF8
- SRXX4
- SRXY3
- hSF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.98 | ||
hub protein | 0.9 | ||
protein domain | 0.85 | ||
biological process | 0.84 | ||
biological term | 0.8 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 937.38 (req: < 5)
Gene RIFs: 175 (req: <= 3)
Antibodies: 377 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 937.38 (req: >= 5)
Gene RIFs: 175 (req: > 3)
Antibodies: 377 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (15)
Reactome (11)
KEGG (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Nuclear Receptor transcription pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Developmental Biology | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Metabolism of proteins | ||||
Nuclear Receptor transcription pathway | ||||
Gene Ontology Terms (38)
Functions (14)
Components (3)
Processes (21)
Items per page:
10
1 – 10 of 14
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (150)
1 – 10 of 150
NR0B1
Family: NR
Novelty: 0.00171069
Score: 0.983
Data Source: STRINGDB
UBE2I
Novelty: 0.00316288
Score: 0.967
Data Source: Reactome,STRINGDB
PIAS1
Family: TF
Novelty: 0.01153358
Score: 0.942
Data Source: STRINGDB
SUMO1
Novelty: 0.00169202
Score: 0.937
Data Source: Reactome,STRINGDB
FOXL2
Family: TF
Novelty: 0.00136796
Score: 0.936
Data Source: STRINGDB
SUMO2
Novelty: 0.00437464
Score: 0.932
Data Source: Reactome,STRINGDB
NRIP1
Novelty: 0.00621822
Score: 0.912
Data Source: STRINGDB
PIAS3
Family: TF
Novelty: 0.01507171
Score: 0.902
Data Source: STRINGDB
MED1
Family: Enzyme
Novelty: 0.01259825
Score: 0.9
Data Source: STRINGDB
SOX9
Family: TF
Novelty: 0.00058844
Score: 0.891
Data Source: STRINGDB
Publication Statistics
PubMed Score 937.38
PubMed score by year
PubTator Score 607.72
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRF
1-70
QKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVL
70-140
PPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLP
140-210
YGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWA
210-280
RRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLR
280-350
AQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLL
350-420
LCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
420-461
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
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