Tbio G3BP1 Ras GTPase-activating protein-binding protein 1

Protein Summary

Description

ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778). This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13283
• Q5HYE9
• G3BP-1

Gene Name

• G3BP1

Ensembl ID

• ENST00000356245
• ENSP00000348578
• ENSG00000145907
• ENST00000394123
• ENSP00000377681
• ENST00000520177
• ENSP00000427810
• ENST00000522367
• ENSP00000428926

Symbol

• G3BP
• G3BP
• HDH-VIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
ligand (protein) perturbation	0.99
disease perturbation	0.96
transcription factor binding site profile	0.96
kinase perturbation	0.95

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Ras Gtpase-activating Protein-binding Protein 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Ras Gtpase-activating Protein-binding Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ras Gtpase-activating Protein-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.14   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 508   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 294.14   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0