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Tbio
G3BP1
Ras GTPase-activating protein-binding protein 1

Protein Summary
Description
ATP- and magnesium-dependent helicase (PubMed:9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PubMed:9889278). Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PubMed:9889278). Phosphorylation-dependent sequence-specific endoribonuclease in vitro (PubMed:11604510). Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PubMed:11604510). May be a regulated effector of stress granule assembly (PubMed:12642610, PubMed:20180778). This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356245
  • ENSP00000348578
  • ENSG00000145907
  • ENST00000394123
  • ENSP00000377681
  • ENST00000520177
  • ENSP00000427810
  • ENST00000522367
  • ENSP00000428926

Symbol
  • G3BP
  • G3BP
  • HDH-VIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
ligand (protein) perturbation
0.99
disease perturbation
0.96
transcription factor binding site profile
0.96
kinase perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.12   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 508   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.12   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 508   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
17.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G3BP stress granule assembly factor 1
VGNC:11950
471711
Macaque
G3BP stress granule assembly factor 1
713884
Mouse
MGI:1351465
27041
Rat
RGD:621140
171092
Dog
G3BP stress granule assembly factor 1
VGNC:41038
479322
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G3BP stress granule assembly factor 1
Macaque
G3BP stress granule assembly factor 1
Mouse
Rat
Dog
G3BP stress granule assembly factor 1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (164)
1 – 10 of 164
NUFIP2
Tbio
Novelty: 0.09366649
p_int: 0.982003126
p_ni: 0.017996874
Score: 0.849
Data Source: BioPlex,STRINGDB
USP10
Tchem
Family: Enzyme
Novelty: 0.05830541
p_int: 0.964204913
p_ni: 0.035795087
Score: 0.996
Data Source: BioPlex,STRINGDB
G3BP2
Tbio
Family: Enzyme
Novelty: 0.04786241
p_int: 0.910457918
p_ni: 0.089542082
Score: 0.846
Data Source: BioPlex,STRINGDB
CAPRIN1
Tbio
Novelty: 0.02340763
Score: 0.947
Data Source: STRINGDB
YBX1
Tbio
Family: TF
Novelty: 0.00132108
Score: 0.898
Data Source: STRINGDB
ABCE1
Tbio
Family: Transporter
Novelty: 0.00529126
Score: 0.891
Data Source: STRINGDB
TIA1
Tbio
Novelty: 0.00264338
Score: 0.883
Data Source: STRINGDB
PABPC1
Tbio
Novelty: 0.00197523
Score: 0.873
Data Source: STRINGDB
TIAL1
Tbio
Novelty: 0.01126806
Score: 0.86
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.857
Data Source: STRINGDB
Publication Statistics
PubMed Score  205.12

PubMed score by year
PubTator Score  92.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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