Tbio STX3 Syntaxin-3

Protein Summary

Description

Potentially involved in docking of synaptic vesicles at presynaptic active zones. The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q13277
• B4DME0
• O43750
• O43751
• Q15360

Gene Name

• STX3

Ensembl ID

• ENST00000337979
• ENSP00000338562
• ENSG00000166900
• ENST00000529177
• ENSP00000433248

Symbol

• STX3A
• STX3A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.92
PubMedID	0.89
disease perturbation	0.87
transcription factor perturbation	0.84
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-3

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.05   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.05   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0