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Tbio
DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

Protein Summary
Description
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250383
  • ENSP00000250383
  • ENSG00000100867
  • ENST00000344777
  • ENSP00000344674
  • ENST00000611765
  • ENSP00000481607

Symbol
  • SDR25C1
  • HEP27
  • SDR25C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
small molecule perturbation
0.89
cellular component
0.82
interacting protein
0.77
cell type or tissue
0.75


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.28   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 476.28   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 2
745339
Rat
RGD:1583909
691464
Dog
dehydrogenase/reductase 2
VGNC:39933
490616
Horse
dehydrogenase/reductase 2 [Source:HGNC Symbol;Acc:HGNC:18349]
C. elegans
178658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 2
Rat
Dog
dehydrogenase/reductase 2
Horse
dehydrogenase/reductase 2 [Source:HGNC Symbol;Acc:HGNC:18349]
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13268-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (22)
1 – 10 of 22
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999999758
p_ni:  2.38e-7
p_wrong:  3e-9
Data Source:  BioPlex
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999997811
p_ni:  0.000002189
Score:  0.188
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.999978149
p_ni:  0.000008227
p_wrong:  0.000013624
Score:  0.313
Data Source:  BioPlex,STRINGDB
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.999966067
p_ni:  0.00002285
p_wrong:  0.000011083
Data Source:  BioPlex
MZF1
Tbio
Family:  TF
Novelty:  0.01193919
p_int:  0.999942371
p_ni:  0.000053929
p_wrong:  0.0000037
Data Source:  BioPlex
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.999675052
p_ni:  0.000166028
p_wrong:  0.00015892
Score:  0.258
Data Source:  BioPlex,STRINGDB
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.999575605
p_ni:  0.000029682
p_wrong:  0.000394713
Score:  0.188
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.998399548
p_ni:  0.001600451
Score:  0.198
Data Source:  BioPlex,STRINGDB
AP3S1
Tbio
Novelty:  0.12425009
p_int:  0.997640772
p_ni:  0.002230287
p_wrong:  0.000128941
Score:  0.202
Data Source:  BioPlex,STRINGDB
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.994926041
p_ni:  0.00183638
p_wrong:  0.003237579
Score:  0.848
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  476.28

PubMed score by year
PubTator Score  87.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer