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Tclin
PTGDR
Prostaglandin D2 receptor

Protein Summary
Description
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306051
  • ENSP00000303424
  • ENSG00000168229
  • ENST00000553372
  • ENSP00000452408

Symbol
  • DP
  • AS1
  • DP1
  • ASRT1
  • PTGDR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.8
microRNA
0.75
tissue sample
0.65
tissue
0.64
histone modification site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1072.17   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1072.17   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 309
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (160)
1 – 10 of 160
GNAS
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
GNAS
Tbio
Novelty:  0.00284739
Score:  0.956
Data Source:  STRINGDB
NPSR1
Tchem
Family:  GPCR
Novelty:  0.00562139
Score:  0.936
Data Source:  STRINGDB
ADCY4
Tbio
Family:  Enzyme
Novelty:  0.00465974
Score:  0.927
Data Source:  STRINGDB
GNG10
Tdark
Novelty:  0.37659459
Score:  0.926
Data Source:  STRINGDB
GPR27
Tbio
Family:  GPCR
Novelty:  0.164488
Score:  0.923
Data Source:  STRINGDB
E2F3
Tbio
Family:  TF
Novelty:  0.00287552
Score:  0.922
Data Source:  STRINGDB
GPR45
Tbio
Family:  GPCR
Novelty:  0.08366919
Score:  0.92
Data Source:  STRINGDB
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Eicosanoid ligand-binding receptors
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Eicosanoid ligand-binding receptors
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
prostaglandin D2 receptor
707918
Mouse
MGI:102966
19214
Rat
RGD:1565108
498475
Dog
prostaglandin D2 receptor
VGNC:45140
610845
Horse
prostaglandin D2 receptor
VGNC:21986
100067254
Species
Name
OMA
EggNOG
Inparanoid
Macaque
prostaglandin D2 receptor
Mouse
Rat
Dog
prostaglandin D2 receptor
Horse
prostaglandin D2 receptor
Publication Statistics
PubMed Score 1072.17
PubMed score by year
PubTator Score 718.82
PubTator score by year
Patents
Patents by year