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Tbio
MAD2L1
Mitotic spindle assembly checkpoint protein MAD2A

Protein Summary
Description
Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296509
  • ENSP00000296509
  • ENSG00000164109
  • ENST00000333047
  • ENSP00000332295

Symbol
  • MAD2
  • MAD2
  • HSMAD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.93
biological process
0.91
histone modification site profile
0.89
gene perturbation
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.45   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 548   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.45   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (509)
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.998984398
p_ni:  0.001015602
Score:  0.343
Data Source:  BioPlex,STRINGDB
PYM1
Tbio
Novelty:  0.04117785
p_int:  0.969685137
p_ni:  0.030314863
Score:  0.325
Data Source:  BioPlex,STRINGDB
CDC16
Tbio
Novelty:  0.00916715
Score:  0.999
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.999
Data Source:  STRINGDB
ANAPC1
Tbio
Family:  Enzyme
Novelty:  0.0521845
Score:  0.999
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.999
Data Source:  Reactome,STRINGDB
PSMD8
Tbio
Family:  Enzyme
Novelty:  0.03053455
Score:  0.999
Data Source:  STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.999
Data Source:  Reactome,STRINGDB
ANAPC7
Tbio
Family:  Enzyme
Novelty:  0.17956785
Score:  0.999
Data Source:  STRINGDB
TRIP13
Tbio
Family:  Enzyme
Novelty:  0.00660506
Score:  0.999
Data Source:  STRINGDB
Pathways (43)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
4
1.1
76.8
refractive error measurement
1
1
1
10.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
76.8
refractive error measurement
1
10.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 2 like 1
VGNC:48884
461661
Mouse
MGI:1860374
56150
Rat
RGD:1310889
297176
Dog
mitotic arrest deficient 2 like 1
476070
Horse
mitotic arrest deficient 2 like 1
VGNC:19884
100072353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitotic arrest deficient 2 like 1
Mouse
Rat
Dog
mitotic arrest deficient 2 like 1
Horse
mitotic arrest deficient 2 like 1
Publication Statistics
PubMed Score 65.45
PubMed score by year
PubTator Score 310.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title