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Tchem
GRM1
Metabotropic glutamate receptor 1

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calciu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282753
  • ENSP00000282753
  • ENSG00000152822
  • ENST00000355289
  • ENSP00000347437
  • ENST00000361719
  • ENSP00000354896
  • ENST00000492807
  • ENSP00000424095
  • ENST00000507907
  • ENSP00000425599

Symbol
  • GPRC1A
  • MGLUR1
  • MGLU1
  • SCA44
  • GPRC1A
  • MGLUR1
  • SCAR13
  • PPP1R85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
protein domain
0.99
trait
0.93
hub protein
0.79
biological process
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 993.3   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 664   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 993.3   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 664   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 161
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
1
1
31.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cathepsin L1 measurement
1
31.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 1
VGNC:9968
463049
Macaque
glutamate metabotropic receptor 1
698736
Mouse
MGI:1351338
14816
Rat
RGD:2742
24414
Dog
glutamate metabotropic receptor 1
VGNC:41508
484024
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 1
Macaque
glutamate metabotropic receptor 1
Mouse
Rat
Dog
glutamate metabotropic receptor 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13255-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (45)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Neurexins and neuroligins
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Neurexins and neuroligins
Gene Ontology Terms (26)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (352)
1 – 10 of 352
HOMER1
Tbio
Novelty: 0.00264721
Score: 0.993
Data Source: Reactome,STRINGDB
HOMER3
Tbio
Novelty: 0.04408998
Score: 0.983
Data Source: Reactome,STRINGDB
HOMER2
Tbio
Novelty: 0.00820449
Score: 0.979
Data Source: Reactome,STRINGDB
DLGAP1
Tbio
Novelty: 0.01576595
Score: 0.975
Data Source: Reactome,STRINGDB
SHANK1
Tbio
Novelty: 0.01475447
Score: 0.973
Data Source: Reactome,STRINGDB
NLGN2
Tbio
Family: Enzyme
Novelty: 0.01613168
Score: 0.963
Data Source: STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.959
Data Source: Reactome,STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.954
Data Source: STRINGDB
HTR2A
Tclin
Family: GPCR
Novelty: 0.00035566
Score: 0.953
Data Source: STRINGDB
SHANK2
Tbio
Novelty: 0.00710548
Score: 0.944
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  993.30

PubMed score by year
PubTator Score  164.99

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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