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Tbio
SRSF6
Serine/arginine-rich splicing factor 6

Protein Summary
Description
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244020
  • ENSP00000244020
  • ENSG00000124193
  • ENST00000483871
  • ENSP00000433544

Symbol
  • SFRS6
  • SRP55
  • B52
  • SFRS6
  • SRP55
  • HEL-S-91
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
virus perturbation
0.98
disease perturbation
0.93
transcription factor perturbation
0.88
transcription factor binding site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.74   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.74   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915246
67996
Rat
RGD:1359241
362264
Dog
serine and arginine rich splicing factor 6
VGNC:54735
403667
Horse
serine and arginine rich splicing factor 6
VGNC:51612
100070669
Cow
serine and arginine rich splicing factor 6
507828
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
serine and arginine rich splicing factor 6
Horse
serine and arginine rich splicing factor 6
Cow
serine and arginine rich splicing factor 6
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (404)
1 – 10 of 404
SAP18
Tbio
Family: Enzyme
Novelty: 0.03918373
p_int: 0.787310357
p_ni: 0.212689643
Score: 0.24
Data Source: BioPlex,STRINGDB
TRA2B
Tbio
Novelty: 0.0146833
Score: 0.998
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.995
Data Source: STRINGDB
SRSF1
Tbio
Novelty: 0.00074446
Score: 0.995
Data Source: STRINGDB
SRSF7
Tbio
Novelty: 0.03712415
Score: 0.995
Data Source: STRINGDB
SRSF9
Tbio
Novelty: 0.03141615
Score: 0.993
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.988
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.986
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.985
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  245.74

PubMed score by year
PubTator Score  63.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer