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Tbio
SRSF5
Serine/arginine-rich splicing factor 5

Protein Summary
Description
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394366
  • ENSP00000377892
  • ENSG00000100650
  • ENST00000553521
  • ENSP00000452123
  • ENST00000553635
  • ENSP00000451391
  • ENST00000557154
  • ENSP00000451088

Symbol
  • HRS
  • SFRS5
  • SRP40
  • HRS
  • SFRS5
  • SRP40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.94
transcription factor binding site profile
0.9
transcription factor
0.76
tissue sample
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.78   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.78   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
42
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
42
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 5
VGNC:12546
453000
Macaque
sushi domain-containing protein 6 [Source:RefSeq peptide;Acc:NP_001181376]
Mouse
MGI:98287
20384
Rat
RGD:3664
29667
Dog
serine and arginine rich splicing factor 5
VGNC:51690
490754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine and arginine rich splicing factor 5
Macaque
sushi domain-containing protein 6 [Source:RefSeq peptide;Acc:NP_001181376]
Mouse
Rat
Dog
serine and arginine rich splicing factor 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13243-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (327)
1 – 10 of 327
RRS1
Tbio
Novelty: 0.01643671
p_int: 0.921793117
p_ni: 0.078206883
Score: 0.194
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.87473888
p_ni: 0.12526112
Score: 0.189
Data Source: BioPlex,STRINGDB
SRSF7
Tbio
Novelty: 0.03712415
Score: 0.987
Data Source: STRINGDB
CWC22
Tbio
Novelty: 0.027689
Score: 0.983
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.983
Data Source: STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
Score: 0.98
Data Source: STRINGDB
U2AF2
Tbio
Novelty: 0.00590935
Score: 0.98
Data Source: STRINGDB
SRSF3
Tbio
Novelty: 0.01015895
Score: 0.979
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.978
Data Source: STRINGDB
HNRNPA1
Tchem
Novelty: 0.0020871
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.78

PubMed score by year
PubTator Score  43.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer