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Tbio
SRSF5
Serine/arginine-rich splicing factor 5

Protein Summary
Description
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394366
  • ENSP00000377892
  • ENSG00000100650
  • ENST00000553521
  • ENSP00000452123
  • ENST00000553635
  • ENSP00000451391
  • ENST00000557154
  • ENSP00000451088

Symbol
  • HRS
  • SFRS5
  • SRP40
  • HRS
  • SFRS5
  • SRP40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.94
transcription factor binding site profile
0.9
transcription factor
0.76
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.98   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.98   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0