SRSF5
Serine/arginine-rich splicing factor 5
Protein Classes
Protein Summary
Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- ENST00000394366
- ENSP00000377892
- ENSG00000100650
- ENST00000553521
- ENSP00000452123
- ENST00000553635
- ENSP00000451391
- ENST00000557154
- ENSP00000451088
- HRS
- SFRS5
- SRP40
- HRS
- SFRS5
- SRP40
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
hub protein | 0.94 | ||
transcription factor binding site profile | 0.9 | ||
transcription factor | 0.76 | ||
tissue sample | 0.71 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.78 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 102 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.78 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 102 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 1 | 1 | 1 | 42 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 1 | 42 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine and arginine rich splicing factor 5 | VGNC:12546 | 453000 | |||||
Macaque | sushi domain-containing protein 6 [Source:RefSeq peptide;Acc:NP_001181376] | |||||||
Mouse | MGI:98287 | 20384 | ||||||
Rat | RGD:3664 | 29667 | ||||||
Dog | serine and arginine rich splicing factor 5 | VGNC:51690 | 490754 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine and arginine rich splicing factor 5 | |||||
Macaque | sushi domain-containing protein 6 [Source:RefSeq peptide;Acc:NP_001181376] | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine and arginine rich splicing factor 5 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (13)
Reactome (10)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Processing of Capped Intron-Containing Pre-mRNA | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | RNA Polymerase II Transcription Termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Metabolism of RNA | ||||
Processing of Capped Intron-Containing Pre-mRNA | ||||
RNA Polymerase II Transcription | ||||
RNA Polymerase II Transcription Termination | ||||
Gene Ontology Terms (19)
Functions (2)
Components (5)
Processes (12)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (327)
1 – 10 of 327
RRS1
Novelty: 0.01643671
p_int: 0.921793117
p_ni: 0.078206883
Score: 0.194
Data Source: BioPlex,STRINGDB
CDX1
Family: TF
Novelty: 0.00815821
p_int: 0.87473888
p_ni: 0.12526112
Score: 0.189
Data Source: BioPlex,STRINGDB
SRSF7
Novelty: 0.03712415
Score: 0.987
Data Source: STRINGDB
CWC22
Novelty: 0.027689
Score: 0.983
Data Source: STRINGDB
HNRNPH1
Novelty: 0.01273351
Score: 0.983
Data Source: STRINGDB
SNRPF
Novelty: 0.17624854
Score: 0.98
Data Source: STRINGDB
U2AF2
Novelty: 0.00590935
Score: 0.98
Data Source: STRINGDB
SRSF3
Novelty: 0.01015895
Score: 0.979
Data Source: STRINGDB
SF3A2
Novelty: 0.03658692
Score: 0.978
Data Source: STRINGDB
HNRNPA1
Novelty: 0.0020871
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score 48.78
PubMed score by year
PubTator Score 43.07
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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