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Tbio
KLRD1
Natural killer cells antigen CD94

Protein Summary
Description
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336164
  • ENSP00000338130
  • ENSG00000134539
  • ENST00000350274
  • ENSP00000310929
  • ENST00000381908
  • ENSP00000371333

Symbol
  • CD94
  • CD94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
molecular function
0.67
tissue sample
0.63
cell line
0.62
biological term
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.69   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 827   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.69   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 827   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor D1
VGNC:8433
450156
Macaque
killer cell lectin like receptor D1
574145
Mouse
MGI:1196275
16643
Rat
RGD:2978
25110
Dog
killer cell lectin like receptor D1
VGNC:42486
611360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
killer cell lectin like receptor D1
Macaque
killer cell lectin like receptor D1
Mouse
Rat
Dog
killer cell lectin like receptor D1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
DAP12 interactions
DAP12 signaling
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (228)
1 – 10 of 228
OSBPL6
Tbio
Novelty: 0.25692861
p_int: 0.999973043
p_ni: 0.000026957
Data Source: BioPlex
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.999968477
p_ni: 0.000031518
p_wrong: 5e-9
Data Source: BioPlex
OSBPL3
Tbio
Novelty: 0.06106368
p_int: 0.999967074
p_ni: 0.000032926
Data Source: BioPlex
KIAA1586
Tdark
Novelty: 2.30999532
p_int: 0.999739149
p_ni: 0.000255534
p_wrong: 0.000005316
Data Source: BioPlex
TMEM183A
Tdark
Novelty: 0.4017284
p_int: 0.997901357
p_ni: 0.00093788
p_wrong: 0.001160762
Data Source: BioPlex
SFXN3
Tbio
Novelty: 0.18698456
p_int: 0.997852144
p_ni: 0.002146335
p_wrong: 0.000001521
Data Source: BioPlex
ATP7A
Tbio
Family: Enzyme
Novelty: 0.00064155
p_int: 0.98837872
p_ni: 0.011610514
p_wrong: 0.000010766
Score: 0.228
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.986028328
p_ni: 0.01397165
p_wrong: 2.2e-8
Data Source: BioPlex
ACAD10
Tbio
Family: Enzyme
Novelty: 0.09858243
p_int: 0.980724127
p_ni: 0.019273662
p_wrong: 0.000002211
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.958884678
p_ni: 0.041115322
Data Source: BioPlex
Publication Statistics
PubMed Score  413.69

PubMed score by year
PubTator Score  236.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer