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Tbio
SLA
Src-like-adapter

Protein Summary
Description
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338087
  • ENSP00000337548
  • ENSG00000155926
  • ENST00000395352
  • ENSP00000378759
  • ENST00000427060
  • ENSP00000394049
  • ENST00000517648
  • ENSP00000428559
  • ENST00000524345
  • ENSP00000427928

Symbol
  • SLAP
  • SLAP1
  • SLA1
  • SLAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.79
PubMedID
0.78
transcription factor perturbation
0.68
kinase perturbation
0.6
cell type or tissue
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
NCOA2
Tbio
Novelty:  0.00510052
p_int:  0.962915444
p_ni:  0.007022818
p_wrong:  0.030061738
Score:  0.68
Data Source:  BioPlex,STRINGDB
FGR
Tchem
Family:  Kinase
Novelty:  0.00262848
Score:  0.956
Data Source:  STRINGDB
HCK
Tclin
Family:  Kinase
Novelty:  0.00237485
Score:  0.954
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.914
Data Source:  STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
Score:  0.914
Data Source:  STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
Score:  0.913
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.911
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.91
Data Source:  STRINGDB
SLMAP
Tbio
Novelty:  0.03974856
Score:  0.907
Data Source:  STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
1
1
0
1.1
51.7
Thyroid preparation use measurement
1
1
1
50.6
eosinophil percentage of leukocytes
1
1
1
45.7
eosinophil count
1
1
1
35
1
1
0
1.2
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.1
51.7
Thyroid preparation use measurement
1
50.6
eosinophil percentage of leukocytes
1
45.7
eosinophil count
1
35
0
1.2
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Src like adaptor
VGNC:14586
464409
Macaque
Src like adaptor
697377
Mouse
MGI:104295
20491
Rat
RGD:631373
338477
Dog
Src like adaptor
VGNC:46202
608259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Src like adaptor
Macaque
Src like adaptor
Mouse
Rat
Dog
Src like adaptor
Publication Statistics
PubMed Score 55.48
PubMed score by year
PubTator Score 725.96
PubTator score by year
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Related Publications
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PMID
Year
Title