Tbio SLA Src-like-adapter

Protein Summary

Description

Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.

Uniprot Accession IDs

• Q13239
• B7Z4J2
• B7Z4L6
• Q6FI01
• Q9UMQ8

Gene Name

• SLA

Ensembl ID

• ENST00000338087
• ENSP00000337548
• ENSG00000155926
• ENST00000395352
• ENSP00000378759
• ENST00000427060
• ENSP00000394049
• ENST00000517648
• ENSP00000428559
• ENST00000524345
• ENSP00000427928

Symbol

• SLAP
• SLAP1
• SLA1
• SLAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.79
PubMedID	0.78
transcription factor perturbation	0.68
kinase perturbation	0.6
cell type or tissue	0.59

Protein Classes

DTO Classes

Src-like-adapter 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.1   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.1   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0