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Tchem
PRKG2
cGMP-dependent protein kinase 2

Protein Summary
Description
Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264399
  • ENSP00000264399
  • ENSG00000138669
  • ENST00000395578
  • ENSP00000378945
  • ENST00000628926
  • ENSP00000486129

Symbol
  • PRKGR2
  • PKG2
  • cGK2
  • cGKII
  • PRKGR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
gene perturbation
0.95
cell type or tissue
0.82
disease perturbation
0.74


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.22   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.22   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
8
12
97.3
BMI-adjusted hip circumference
3
6
8
93.3
BMI-adjusted waist circumference
6
7
11
86.8
Myopia
1
1
0
1.1
75.7
refractive error measurement
1
1
1
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
12
97.3
BMI-adjusted hip circumference
8
93.3
BMI-adjusted waist circumference
11
86.8
Myopia
0
1.1
75.7
refractive error measurement
1
72.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase, cGMP-dependent, type II
461217
Macaque
protein kinase, cGMP-dependent, type II
696308
Mouse
MGI:108173
19092
Rat
RGD:3401
25523
Dog
protein kinase cGMP-dependent 2
VGNC:44990
100855930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase, cGMP-dependent, type II
Macaque
protein kinase, cGMP-dependent, type II
Mouse
Rat
Dog
protein kinase cGMP-dependent 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13237-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (31)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Hemostasis
Reactome
Metabolism
Reactome
Metabolism of cofactors
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Hemostasis
Metabolism
Metabolism of cofactors
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (148)
1 – 10 of 148
UNC119
Tchem
Novelty:  0.00396292
p_int:  1
Score:  0.313
Data Source:  BioPlex,STRINGDB
MRVI1
Tbio
Novelty:  0.02987514
Score:  0.986
Data Source:  Reactome,STRINGDB
VASP
Tbio
Novelty:  0.00041984
Score:  0.954
Data Source:  STRINGDB
PTS
Tbio
Family:  Enzyme
Novelty:  0.00279396
Score:  0.94
Data Source:  Reactome,STRINGDB
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.923
Data Source:  Reactome,STRINGDB
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
Score:  0.923
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.922
Data Source:  Reactome,STRINGDB
GUCY1A2
Tclin
Family:  Enzyme
Novelty:  0.05335767
Score:  0.919
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.912
Data Source:  Reactome,STRINGDB
GUCY1A1
Tclin
Family:  Enzyme
Novelty:  0.02289791
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  71.22

PubMed score by year
PubTator Score  42.42

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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