Tchem MAP3K1 Mitogen-activated protein kinase kinase kinase 1

Protein Summary

Description

Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q13233

Gene Name

• MAP3K1

Ensembl ID

• ENST00000399503
• ENSP00000382423
• ENSG00000095015

Symbol

• MAPKKK1
• MEKK
• MEKK1
• MEKK
• MEKK1
• SRXY6
• MEKK 1
• MAPKKK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
molecular function	1
protein domain	0.99
biological process	0.97
drug perturbation	0.96

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste11 Family / Mitogen-activated Protein Kinase Kinase Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.67   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 416   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 244.67   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0