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Tchem
MAP3K1
Mitogen-activated protein kinase kinase kinase 1

Protein Summary
Description
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624). The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399503
  • ENSP00000382423
  • ENSG00000095015

Symbol
  • MAPKKK1
  • MEKK
  • MEKK1
  • MEKK
  • MEKK1
  • SRXY6
  • MEKK 1
  • MAPKKK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
0.99
biological process
0.97
drug perturbation
0.96


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.17   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 416   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.17   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 416   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
E6201
Rendered image for E6201
CHEMBL318804
Rendered image for CHEMBL318804
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
12
0
1.3
97.4
waist circumference
1
2
2
90.8
waist-hip ratio
1
2
2
88.2
BMI-adjusted waist-hip ratio
1
2
2
87.6
BMI-adjusted waist circumference
1
1
1
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.4
waist circumference
2
90.8
waist-hip ratio
2
88.2
BMI-adjusted waist-hip ratio
2
87.6
BMI-adjusted waist circumference
1
79.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 1
VGNC:8626
471543
Macaque
mitogen-activated protein kinase kinase kinase 1
710979
Mouse
MGI:1346872
26401
Rat
RGD:620966
116667
Dog
mitogen-activated protein kinase kinase kinase 1
VGNC:42966
478061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 1
Macaque
mitogen-activated protein kinase kinase kinase 1
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q13233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (92)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
FCERI mediated MAPK activation
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
FCERI mediated MAPK activation
Fc epsilon receptor (FCERI) signaling
Immune System
Innate Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (207)
1 – 10 of 207
TOM1
Tbio
Novelty:  0.00725956
p_int:  0.999999707
p_ni:  9.4e-8
p_wrong:  1.99e-7
Data Source:  BioPlex
TRAF3
Tbio
Novelty:  0.0022525
Score:  0.991
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.99
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.989
Data Source:  Reactome,STRINGDB
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
Score:  0.988
Data Source:  Reactome,STRINGDB
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.988
Data Source:  Reactome,STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.987
Data Source:  STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.987
Data Source:  Reactome,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
Score:  0.986
Data Source:  Reactome,STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.972
Data Source:  STRINGDB
Publication Statistics
PubMed Score  217.17

PubMed score by year
PubTator Score  226.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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