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Tbio
GPS2
G protein pathway suppressor 2

Protein Summary
Description
Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380728
  • ENSP00000370104
  • ENSG00000132522
  • ENST00000389167
  • ENSP00000379841

Symbol
  • AMF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
tissue sample
0.83
biological process
0.78
transcription factor binding site profile
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.23   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.23   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein pathway suppressor 2
VGNC:9309
455229
Mouse
MGI:1891751
56310
Rat
RGD:1562746
497941
Dog
G protein pathway suppressor 2
VGNC:41456
100855803
Horse
G protein pathway suppressor 2
VGNC:18561
100061712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein pathway suppressor 2
Mouse
Rat
Dog
G protein pathway suppressor 2
Horse
G protein pathway suppressor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13227-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Disease
Gene expression (Transcription)
Generic Transcription Pathway
Protein-Protein Interactions (90)
1 – 10 of 90
ANKRD11
Tbio
Novelty: 0.01106723
p_int: 1
Score: 0.372
Data Source: BioPlex,STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
p_int: 0.999999998
p_ni: 2e-9
Score: 0.986
Data Source: BioPlex,Reactome,STRINGDB
PPFIA3
Tbio
Novelty: 0.03837299
p_int: 0.999999853
p_ni: 1.47e-7
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
TBL1X
Tbio
Novelty: 0.00027212
p_int: 0.999999272
p_ni: 7.28e-7
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
TBL1Y
Tbio
p_int: 0.999999109
p_ni: 7e-9
p_wrong: 8.84e-7
Data Source: BioPlex
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999998747
p_ni: 4.33e-7
p_wrong: 8.21e-7
Score: 0.705
Data Source: BioPlex,STRINGDB
DAPK3
Tchem
Family: Kinase
Novelty: 0.01551494
p_int: 0.999998571
p_ni: 0.000001429
Score: 0.177
Data Source: BioPlex,STRINGDB
NCOR1
Tchem
Family: TF
Novelty: 0.0021926
p_int: 0.999997548
p_ni: 0.000002452
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
PPFIA1
Tbio
Novelty: 0.01904029
p_int: 0.999996242
p_ni: 0.000003758
Data Source: BioPlex
TBL1XR1
Tbio
Novelty: 0.00503043
p_int: 0.999992558
p_ni: 0.000007428
p_wrong: 1.3e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  94.23

PubMed score by year
PubTator Score  56.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer