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Tclin
GRIN2B
Glutamate receptor ionotropic, NMDA 2B

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plastici ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000609686
  • ENSP00000477455
  • ENSG00000273079

Symbol
  • NMDAR2B
  • NR3
  • MRD6
  • NR2B
  • hNR3
  • EIEE27
  • GluN2B
  • NMDAR2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
trait
1
ligand (chemical)
0.94
biological term
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3002.62   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 1245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3002.62   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 1245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
85.5
refractive error measurement
2
2
1
6.2
81.6
self reported educational attainment
1
1
1
65.5
risk-taking behaviour
2
2
2
37.1
systolic blood pressure
1
1
1
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
85.5
refractive error measurement
1
6.2
81.6
self reported educational attainment
1
65.5
risk-taking behaviour
2
37.1
systolic blood pressure
1
30.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor NMDA type subunit 2B
698571
Mouse
MGI:95821
14812
Rat
RGD:2738
24410
Dog
glutamate ionotropic receptor NMDA type subunit 2B
VGNC:41493
494009
Horse
glutamate ionotropic receptor NMDA type subunit 2B
VGNC:18589
100063746
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutamate ionotropic receptor NMDA type subunit 2B
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 2B
Horse
glutamate ionotropic receptor NMDA type subunit 2B
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13224-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (69)
Activated NTRK2 signals through FYN (R-HSA-9032500)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FYN
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FYN
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Axon guidance
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Gene Ontology Terms (34)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (327)
1 – 10 of 327
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
p_int: 0.999999794
p_wrong: 2.06e-7
Score: 0.937
Data Source: BioPlex,Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00057285
Score: 0.997
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.992
Data Source: Reactome,STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.991
Data Source: Reactome,STRINGDB
DLG3
Tbio
Novelty: 0.01196565
Score: 0.991
Data Source: Reactome,STRINGDB
DLG2
Tbio
Novelty: 0.00999909
Score: 0.985
Data Source: Reactome,STRINGDB
CAMK2G
Tchem
Family: Kinase
Novelty: 0.04642387
Score: 0.982
Data Source: Reactome,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.982
Data Source: Reactome,STRINGDB
NTRK2
Tclin
Family: Kinase
Novelty: 0.00054534
Score: 0.98
Data Source: Reactome,STRINGDB
CAMK2A
Tchem
Family: Kinase
Novelty: 0.00534906
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  3002.62

PubMed score by year
PubTator Score  798.74

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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