You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
GRIN2B
Glutamate receptor ionotropic, NMDA 2B

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735, PubMed:26875626). In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plastici ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000609686
  • ENSP00000477455
  • ENSG00000273079

Symbol
  • NMDAR2B
  • NR3
  • MRD6
  • NR2B
  • hNR3
  • EIEE27
  • GluN2B
  • NMDAR2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
trait
1
ligand (chemical)
0.94
biological term
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3374.05   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 1245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3374.05   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 1245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 216
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5