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Tbio
PAPPA
Pappalysin-1

Protein Summary
Description
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328252
  • ENSP00000330658
  • ENSG00000182752

Symbol
  • PAPA
  • DIPLA1
  • PAPP-A
  • PAPPA1
  • ASBABP2
  • IGFBP-4ase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.92
protein domain
0.92
transcription factor perturbation
0.88
PubMedID
0.86
gene perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1727.72   (req: < 5)
Gene RIFs: 191   (req: <= 3)
Antibodies: 799   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1727.72   (req: >= 5)
Gene RIFs: 191   (req: > 3)
Antibodies: 799   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
IGFBP4
Tchem
Novelty:  0.00286837
Score:  0.992
Data Source:  Reactome,STRINGDB
ANP32E
Tbio
Novelty:  0.06885748
Score:  0.99
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.978
Data Source:  Reactome,STRINGDB
IGFBP5
Tchem
Novelty:  0.0025185
Score:  0.964
Data Source:  Reactome,STRINGDB
IGF2
Tbio
Novelty:  0.00021277
Score:  0.956
Data Source:  Reactome,STRINGDB
PRG2
Tbio
Novelty:  0.00548995
Score:  0.913
Data Source:  STRINGDB
IGFALS
Tbio
Novelty:  0.0287658
Score:  0.913
Data Source:  Reactome,STRINGDB
ANP32A
Tbio
Novelty:  0.00567095
Score:  0.885
Data Source:  STRINGDB
LGALS13
Tbio
Novelty:  0.00695816
Score:  0.834
Data Source:  STRINGDB
PGF
Tclin
Novelty:  0.00061576
Score:  0.737
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
87.9
sex hormone-binding globulin measurement
4
3
4
85.8
FEV/FEC ratio
1
1
1
78.5
peak expiratory flow
1
1
1
75.2
brain stem volume measurement
1
1
0
9.7
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
87.9
sex hormone-binding globulin measurement
4
85.8
FEV/FEC ratio
1
78.5
peak expiratory flow
1
75.2
brain stem volume measurement
0
9.7
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pappalysin 1
VGNC:9215
464690
Macaque
pappalysin 1
706783
Mouse
MGI:97479
18491
Dog
pappalysin 1
VGNC:44256
481692
Horse
pappalysin 1
VGNC:21151
100033920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pappalysin 1
Macaque
pappalysin 1
Mouse
Dog
pappalysin 1
Horse
pappalysin 1
Publication Statistics
PubMed Score 1727.72
PubMed score by year
PubTator Score 1272.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title