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Tbio
ERCC8
DNA excision repair protein ERCC-8

Protein Summary
Description
Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265038
  • ENSP00000265038
  • ENSG00000049167

Symbol
  • CKN1
  • CSA
  • CSA
  • CKN1
  • UVSS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.76
protein domain
0.73
cell type or tissue
0.68
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.71   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.71   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
98.1
self reported educational attainment
4
3
4
1
94.9
mathematical ability
1
2
2
90.7
household income
2
4
4
89.8
smoking status measurement
2
2
2
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
98.1
self reported educational attainment
4
1
94.9
mathematical ability
2
90.7
household income
4
89.8
smoking status measurement
2
80
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
VGNC:6864
471534
Macaque
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
693362
Mouse
MGI:1919241
71991
Rat
RGD:1311570
310071
Dog
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
VGNC:40446
487225
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Macaque
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Mouse
Rat
Dog
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13216-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Metabolism of proteins
Gene Ontology Terms (24)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (197)
1 – 10 of 197
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999114271
p_ni:  0.000001722
p_wrong:  0.000884007
Score:  0.364
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999013976
p_ni:  0.000001548
p_wrong:  0.000984477
Data Source:  BioPlex
RRP9
Tbio
Novelty:  0.07232317
p_int:  0.785765979
p_ni:  0.000002149
p_wrong:  0.214231872
Score:  0.24
Data Source:  BioPlex,STRINGDB
DDB1
Tbio
Novelty:  0.00345896
Score:  0.997
Data Source:  Reactome,STRINGDB
ERCC4
Tbio
Family:  Enzyme
Novelty:  0.01076913
Score:  0.98
Data Source:  STRINGDB
XAB2
Tbio
Novelty:  0.04104647
Score:  0.98
Data Source:  STRINGDB
ERCC5
Tchem
Family:  Enzyme
Novelty:  0.00819696
Score:  0.979
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.977
Data Source:  STRINGDB
UVSSA
Tbio
Novelty:  0.06728258
Score:  0.975
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.974
Data Source:  STRINGDB
Publication Statistics
PubMed Score  37.71

PubMed score by year
PubTator Score  2063.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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