You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DDX10
Probable ATP-dependent RNA helicase DDX10

Protein Summary
Description
Putative ATP-dependent RNA helicase. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322536
  • ENSP00000314348
  • ENSG00000178105

Symbol
  • Dbp4
  • HRH-J8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
transcription factor perturbation
0.8
disease perturbation
0.79
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (363)
1 – 10 of 363
SRFBP1
Tbio
Novelty: 0.10070972
p_int: 0.985839763
p_ni: 0.014160237
Score: 0.865
Data Source: BioPlex,STRINGDB
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.969009097
p_ni: 0.030990903
Data Source: BioPlex
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.960427652
p_ni: 0.039572348
Score: 0.941
Data Source: BioPlex,STRINGDB
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.935281683
p_ni: 0.064718317
Score: 0.331
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.932221447
p_ni: 0.067778553
Score: 0.196
Data Source: BioPlex,STRINGDB
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.889913976
p_ni: 0.110086024
Score: 0.512
Data Source: BioPlex,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.881806755
p_ni: 0.118193245
Data Source: BioPlex
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.878487483
p_ni: 0.121512517
Score: 0.233
Data Source: BioPlex,STRINGDB
NOL12
Tbio
Novelty: 0.15925205
p_int: 0.8771559
p_ni: 0.1228441
Score: 0.666
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.866749234
p_ni: 0.133250766
Score: 0.911
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  30.66

PubMed score by year
PubTator Score  9.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer