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Tbio
PSMD2
26S proteasome non-ATPase regulatory subunit 2

Protein Summary
Description
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310118
  • ENSP00000310129
  • ENSG00000175166
  • ENST00000435761
  • ENSP00000402618
  • ENST00000439383
  • ENSP00000416028

Symbol
  • TRAP2
  • S2
  • P97
  • RPN1
  • TRAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
biological process
0.98
disease perturbation
0.98
drug perturbation
0.87
histone modification site profile
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 507   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (424)
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.993361552
p_ni:  0.006638448
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD13
Tbio
Family:  Enzyme
Novelty:  0.04204417
p_int:  0.984033727
p_ni:  0.015966273
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD4
Tbio
Family:  Enzyme
Novelty:  0.00614538
p_int:  0.961428001
p_ni:  0.038571999
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMD5
Tbio
Family:  Enzyme
Novelty:  0.00070666
p_int:  0.960031701
p_ni:  0.039968299
Score:  0.991
Data Source:  BioPlex,STRINGDB
UCHL5
Tbio
Family:  Enzyme
Novelty:  0.01486265
p_int:  0.956302526
p_ni:  0.043697474
Score:  0.994
Data Source:  BioPlex,STRINGDB
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.944931982
p_ni:  0.055068018
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMB9
Tchem
Family:  Enzyme
Novelty:  0.0016249
p_int:  0.937470584
p_ni:  0.062529416
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCDC74B
Tdark
Novelty:  1.7435743
p_int:  0.934794449
p_ni:  0.065205551
Score:  0.827
Data Source:  BioPlex,STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
p_int:  0.934313134
p_ni:  0.065686866
Score:  0.999
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.881573055
p_ni:  0.118426945
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (160)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 149
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
9
12
99.5
platelet count
5
9
15
99.4
appendicular lean mass
4
2
4
92.2
hematological measurement
1
1
1
84.2
daytime rest measurement
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
12
99.5
platelet count
15
99.4
appendicular lean mass
4
92.2
hematological measurement
1
84.2
daytime rest measurement
1
74.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 2
VGNC:9691
460887
Macaque
proteasome 26S subunit, non-ATPase 2
705035
Mouse
MGI:1096584
21762
Rat
RGD:1305752
287984
Dog
proteasome 26S subunit, non-ATPase 2
VGNC:45111
478654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome 26S subunit, non-ATPase 2
Macaque
proteasome 26S subunit, non-ATPase 2
Mouse
Rat
Dog
proteasome 26S subunit, non-ATPase 2
Publication Statistics
PubMed Score 30.62
PubMed score by year
PubTator Score 25.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title