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Tbio
CBLB
E3 ubiquitin-protein ligase CBL-B

Protein Classes
Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264122
  • ENSP00000264122
  • ENSG00000114423
  • ENST00000394030
  • ENSP00000377598
  • ENST00000403724
  • ENSP00000384816
  • ENST00000405772
  • ENSP00000384938

Symbol
  • RNF56
  • Cbl-b
  • RNF56
  • Nbla00127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.99
hub protein
0.98
biological process
0.89
transcription factor binding site profile
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.29   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.29   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
5
95.5
2
2
0
1.2
83.3
glomerular filtration rate
1
1
1
22
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
95.5
0
1.2
83.3
glomerular filtration rate
1
22
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene B
VGNC:10371
460566
Macaque
Cbl proto-oncogene B
703879
Mouse
MGI:2146430
208650
Rat
RGD:620535
171136
Dog
Cbl proto-oncogene B
VGNC:38759
487965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Cbl proto-oncogene B
Macaque
Cbl proto-oncogene B
Mouse
Rat
Dog
Cbl proto-oncogene B
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13191-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (357)
1 – 10 of 357
GRB2
Tchem
Novelty: 0.00091605
p_int: 0.999999989
p_ni: 2e-9
p_wrong: 9e-9
Score: 0.895
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999999741
p_ni: 2.59e-7
Score: 0.721
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.997
Data Source: STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
Score: 0.996
Data Source: STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.995
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.995
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.995
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.994
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.986
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.29

PubMed score by year
PubTator Score  133.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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