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Tbio
STX5
Syntaxin-5

Protein Summary
Description
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. This gene encodes a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for v-SNAREs (vesicle-SNAP receptors), permitting specific synaptic vesicle docking and fusion. The encoded protein regulates endoplasmic reticulum to Golgi transport and plays a critical role in autophagy. Autoantibodies targeting the encoded protein may be a diagnostic marker for endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294179
  • ENSP00000294179
  • ENSG00000162236
  • ENST00000377897
  • ENSP00000367129
  • ENST00000394690
  • ENSP00000378182

Symbol
  • STX5A
  • SED5
  • STX5A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.86
cellular component
0.74
transcription factor perturbation
0.74
tissue
0.68
transcription factor binding site profile
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.27   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.27   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 5
VGNC:992
451268
Macaque
syntaxin 5
718435
Mouse
MGI:1928483
56389
Rat
RGD:68426
65134
Dog
syntaxin 5
VGNC:46957
483779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 5
Macaque
syntaxin 5
Mouse
Rat
Dog
syntaxin 5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Gene Ontology Terms (25)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (299)
1 – 10 of 299
SEC22B
Tbio
Novelty: 0.03035448
p_int: 0.999864755
p_ni: 0.000135245
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
INSYN2
Tdark
Novelty: 2.55244594
p_int: 0.999795179
p_ni: 0.000204821
Data Source: BioPlex
VAMP5
Tbio
Novelty: 0.09958312
p_int: 0.999618142
p_ni: 0.000381858
Score: 0.843
Data Source: BioPlex,STRINGDB
FAAP100
Tdark
Novelty: 0.1698504
p_int: 0.999582396
p_ni: 0.000417604
Score: 0.515
Data Source: BioPlex,STRINGDB
TNPO3
Tbio
Novelty: 0.01709028
p_int: 0.999310181
p_ni: 0.000689819
Score: 0.234
Data Source: BioPlex,STRINGDB
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.999284317
p_ni: 0.000715683
Score: 0.513
Data Source: BioPlex,STRINGDB
STX6
Tbio
Novelty: 0.01494028
p_int: 0.998092967
p_ni: 0.001907032
p_wrong: 1e-9
Score: 0.991
Data Source: BioPlex,STRINGDB
VAMP4
Tbio
Novelty: 0.02949854
p_int: 0.997551113
p_ni: 0.002448887
Score: 0.979
Data Source: BioPlex,STRINGDB
STX7
Tbio
Novelty: 0.03109969
p_int: 0.996017001
p_ni: 0.003982993
p_wrong: 6e-9
Score: 0.942
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.0259034
p_int: 0.995350756
p_ni: 0.004649244
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.27

PubMed score by year
PubTator Score  41.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer