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Tchem
STK3
Serine/threonine-protein kinase 3

Protein Summary
Description
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419617
  • ENSP00000390500
  • ENSG00000104375
  • ENST00000523601
  • ENSP00000429744

Symbol
  • KRS1
  • MST2
  • KRS1
  • MST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
1
biological process
0.93
hub protein
0.85
protein domain
0.85


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.59   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
22.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
22.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 3
VGNC:6575
472829
Macaque
serine/threonine kinase 3
707425
Mouse
MGI:1928487
56274
Rat
RGD:68412
65189
Dog
serine/threonine kinase 3
VGNC:46911
475045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine/threonine kinase 3
Macaque
serine/threonine kinase 3
Mouse
Rat
Dog
serine/threonine kinase 3
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q13188-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (37)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (97)
1 – 10 of 97
RASSF2
Tbio
Novelty: 0.031565
p_int: 0.9999997
p_ni: 3e-7
Score: 0.962
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00137149
p_int: 0.999998447
p_ni: 0.000001553
Score: 0.985
Data Source: BioPlex,STRINGDB
RASSF6
Tbio
Novelty: 0.04940382
p_int: 0.999954454
p_ni: 0.000045546
Score: 0.963
Data Source: BioPlex,STRINGDB
SAV1
Tbio
Novelty: 0.00962335
p_int: 0.99981225
p_ni: 0.00018775
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.999402989
p_ni: 0.000597011
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999009992
p_ni: 0.000990008
Score: 0.212
Data Source: BioPlex,STRINGDB
ZNF554
Tdark
Family: TF
Novelty: 1.57478216
p_int: 0.997876146
p_ni: 0.002123854
Data Source: BioPlex
ZNF133
Tbio
Family: TF
Novelty: 0.20117958
p_int: 0.981859108
p_ni: 0.018140892
Score: 0.435
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.981852089
p_ni: 0.018147911
Data Source: BioPlex
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.977451729
p_ni: 0.022548271
Data Source: BioPlex
Publication Statistics
PubMed Score  17.59

PubMed score by year
PubTator Score  102.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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