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Tchem
STK3
Serine/threonine-protein kinase 3

Protein Summary
Description
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419617
  • ENSP00000390500
  • ENSG00000104375
  • ENST00000523601
  • ENSP00000429744

Symbol
  • KRS1
  • MST2
  • KRS1
  • MST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
1
biological process
0.93
hub protein
0.85
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 424   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Gene Ontology Terms (37)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (97)
1 – 10 of 97
RASSF2
Tbio
Novelty: 0.03654796
p_int: 0.9999997
p_ni: 3e-7
Score: 0.962
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00155893
p_int: 0.999998447
p_ni: 0.000001553
Score: 0.985
Data Source: BioPlex,STRINGDB
RASSF6
Tbio
Novelty: 0.06715848
p_int: 0.999954454
p_ni: 0.000045546
Score: 0.963
Data Source: BioPlex,STRINGDB
SAV1
Tbio
Novelty: 0.01342169
p_int: 0.99981225
p_ni: 0.00018775
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
KIF2B
Tbio
Novelty: 0.20461189
p_int: 0.999402989
p_ni: 0.000597011
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00393331
p_int: 0.999009992
p_ni: 0.000990008
Score: 0.212
Data Source: BioPlex,STRINGDB
ZNF554
Tdark
Family: TF
p_int: 0.997876146
p_ni: 0.002123854
Data Source: BioPlex
ZNF133
Tbio
Family: TF
Novelty: 0.17529215
p_int: 0.981859108
p_ni: 0.018140892
Score: 0.435
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.0022428
p_int: 0.981852089
p_ni: 0.018147911
Data Source: BioPlex
VAPB
Tbio
Novelty: 0.00566042
p_int: 0.977451729
p_ni: 0.022548271
Data Source: BioPlex
Publication Statistics
PubMed Score  8.54

PubMed score by year
PubTator Score  102.3

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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