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Tbio
CBX3
Chromobox protein homolog 3

Protein Summary
Description
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitement of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a componen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337620
  • ENSP00000336687
  • ENSG00000122565
  • ENST00000396386
  • ENSP00000379670

Symbol
  • HECH
  • HP1-GAMMA
  • HP1Hs-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
interacting protein
0.97
transcription factor binding site profile
0.9
kinase perturbation
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.64   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.64   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.828116926
p_ni:  0.171883074
Score:  0.958
Data Source:  BioPlex,Reactome,STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
Score:  0.98
Data Source:  Reactome,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
Score:  0.979
Data Source:  STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
Score:  0.977
Data Source:  Reactome,STRINGDB
L3MBTL2
Tbio
Family:  Epigenetic
Novelty:  0.11193867
Score:  0.966
Data Source:  Reactome,STRINGDB
HIST2H3A
Tbio
Novelty:  0.02749981
Score:  0.966
Data Source:  Reactome,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
Score:  0.963
Data Source:  Reactome,STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.963
Data Source:  STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
Score:  0.963
Data Source:  STRINGDB
H3F3C
Tbio
Novelty:  0.07135811
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (R-HSA-427389)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Positive epigenetic regulation of rRNA expression
Name
Explore in Pharos
Explore in Source
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Positive epigenetic regulation of rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
3
3
81.4
waist-hip ratio
1
3
3
80.5
sex hormone-binding globulin measurement
2
1
2
52
waist circumference
1
1
1
8
BMI-adjusted waist circumference
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
81.4
waist-hip ratio
3
80.5
sex hormone-binding globulin measurement
2
52
waist circumference
1
8
BMI-adjusted waist circumference
1
4.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromobox 3
VGNC:4297
463300
Macaque
chromobox protein homolog 3-like
695847
Mouse
MGI:108515
12417
Dog
chromobox 3
482015
Horse
chromobox 3
VGNC:51930
100054158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromobox 3
Macaque
chromobox protein homolog 3-like
Mouse
Dog
chromobox 3
Horse
chromobox 3
Publication Statistics
PubMed Score 139.64
PubMed score by year
PubTator Score 75.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title